手术联合5-氨基酮戊酸光动力疗法治疗日光性角化病13例临床分析  

Clinical Analysis of Surgical Operation Combined with ALA-PDT in the Treatment of 13 Cases of Actinic Keratosis

作　　者：郑渊[1] 董达科[1] 翟建新[1] 蒋屏东[1] 戚稼[1] 倪菁菁[1] 夏汝山[1] 

机构地区：[1]南京医科大学附属无锡二院皮肤科,江苏无锡214000

出　　处：《中国医学文摘（皮肤科学）》2013年第6期340-341,415,共3页China Medical Abstracts(Dermatology)

摘　　要：目的分析手术联合5-氨基酮戊酸光动力疗法(ALA-PDT)治疗日光性角化病(AK)的疗效。方法将29例患者随机分为治疗组(13例)和对照组(16例),治疗组采取手术切除皮损,于术后第2天开始ALAPDT治疗,对照组皮损予ALA-PDT治疗,均1次/周,共3~7次,随访15~36个月。结果治疗组完全反应率(100%)显著优于对照组(68.75%),差异有统计学意义(P【0.05)。结论手术联合ALA-PDT是治疗AK的一种有效、安全的方法。Objective To analyse the clinical efficiency of surgical operation combined with 5-aminolevulinic acid photodynamic therapy(ALA-PDT) in the treatment of actinic keratosis(AK).Methods Twenty-nine patients were randomly divided into treatment group(13 cases) and control group(16 cases).Treatment group: received surgical operation,then ALA-PDT from the next day after operation; control group : received ALA-PDT.The two groups were respectively received 3~7 times of ALA-PDT(once a week),then follow-up of 15~36 months.Results The complete remission rate of treatment group(100%) is better than that of control group(68.75%).The difference between them had statistical significance(P < 0.05).Conclusion Treating AK with surgical operation combined with ALA-PDT is effective and safe.

关 键 词：日光性角化病 手术 5-氨基酮戊酸光动力疗法 

分 类 号：R739.5[医药卫生—肿瘤]