Extra-intestinal and long term consequences of Giardia duodenalis infections  

作　　者：Marie CM Halliez André G Buret 

机构地区：[1]Department of Biological Sciences,Inflammation Research Network,University of Calgary,Calgary,Alberta,AB T2N 1N4,Canada [2]Parasitology Department,Rouen University Hospital & EA 3800 [3]Institute for Biomedical & Research,University of Rouen,Rouen,76183,France

出　　处：《World Journal of Gastroenterology》2013年第47期8974-8985,共12页世界胃肠病学杂志（英文版）

基　　金：Supported by Grants from the Natural Sciences and Engineering Research Council of Canada(individual operating and CREATE),the France-Canada Research Fund;the"Ministère de l’enseignement supérieur et de la recherche",French Ministry of Secondary Education and Research

摘　　要：Giardiasis is the most common waterborne parasitic infection of the human intestine worldwide.The etiological agent,Giardia duodenalis(syn.G.intestinalis,G.lamblia),is a flagellated,binucleated protozoan parasite which infects a wide array of mammalian hosts.Human giardiasis is a true cosmopolitan pathogen,with highest prevalence in developing countries.Giardiasis can present with a broad range of clinical manifestations from asymptomatic,to acute or chronic diarrheal disease associated with abdominal pain and nausea.Most infections are self-limiting,although re-infection and chronic infection can occur.Recent evidence indicating that Giardia may cause chronic post-infectious gastrointestinal complications have made it a topic of intense research.The causes of the post-infectious clinical manifestations due to Giardia,even after complete elimination of the parasite,remain obscure.This review offers a state-of-the-art discussion on the long-term consequences of Giardia infections,from extra-intestinal manifestations,growth and cognitive deficiencies,to post-infectious irritable bowel syndrome.The discussion also sheds light on some of the novel mechanisms recently implicated in the production of these postinfectious manifestations.Giardiasis is the most common waterborne parasitic infection of the human intestine worldwide. The etiological agent, Giardia duodenalis (syn. G. intestinalis, G. lamblia), is a flagellated, binucleated protozoan parasite which infects a wide array of mammalian hosts. Human giardiasis is a true cosmopolitan pathogen, with highest prevalence in developing countries. Giardiasis can present with a broad range of clinical manifestations from asymptomatic, to acute or chronic diarrheal disease associated with abdominal pain and nausea. Most infections are self-limiting, although re-infection and chronic infection can occur. Recent evidence indicating that Giardia may cause chronic post-infectious gastrointestinal complications have made it a topic of intense research. The causes of the post-infectious clinical manifestations due to Giardia, even after complete elimination of the parasite, remain obscure. This review offers a state-of-the-art discussion on the long-term consequences of Giardia infections, from extra-intestinal manifestations, growth and cognitive deficiencies, to post-infectious irritable bowel syndrome. The discussion also sheds light on some of the novel mechanisms recently implicated in the production of these post-infectious manifestations.

关 键 词：GIARDIASIS Inflammatory disorders Extraintestinal MANIFESTATIONS of ENTERITIS Failure to thrive Post-infectious IRRITABLE BOWEL syndrome 

分 类 号：R531.7[医药卫生—内科学]