Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany  

作　　者：Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe 

机构地区：[1]Klinik für Gastroenterologie,GI Onkologie und Infektiologie,Vivantes Klinikum Am Urban,10967 Berlin,Germany [2]Gemeinsames Krebsregister der Lander Berlin,Brandenburg,Mecklenburg-Vorpommern,Sachsen-Anhalt und der Freistaaten Sachsen und Thüringen (GKR),10967 Berlin,Germany [3]Institut für Pathologie,Vivantes Netzwerk für Gesundheit GmbH,10967 Berlin,Germany [4]Institut für Physiologie,Charité-Universitatsmedizin,10117 Berlin,Germany [5]Charité-Universitatsmedizin Berlin,HNO-Klinik,Campus Virchow Klinikum,13353 Berlin,Germany

出　　处：《World Journal of Gastroenterology》2013年第47期9012-9019,共8页世界胃肠病学杂志（英文版）

摘　　要：AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET AIM: To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors (GEP-NET) in Germany, we analyzed two time periods 1976-1988 and 1998-2006.

关 键 词：NEUROENDOCRINE Tumor Epidemiology GASTRINOMA INSULINOMA Endoscopy German history REUNIFICATION Second malignancy 

分 类 号：R735[医药卫生—肿瘤]