联合使用放疗和新福菌素化疗治疗晚期鼻咽癌的疗效观察  

Therapeutic effect of sinoactinomycin-chemotherapy with radiotherapy for advanced nasopharyngeal carcinoma

作　　者：李艾恩[1] 李凯新[1] 陈轶杰[1] 

机构地区：[1]福建医科大学附属泉州市第一医院放疗科,福建泉州362000

出　　处：《求医问药（下半月）》2013年第11期114-115,共2页Seek Medical and Ask The Medicine

摘　　要：目的:观察在晚期鼻咽癌同步放疗中应用新福菌素的近期疗效和毒副作用。方法:将2011年4月至2012年4月我院收治的50例经病理诊断证实患有鼻咽癌的患者随机分为治疗组和对照组,每组各25例患者。为对照组患者仅进行单纯的放疗,为治疗组患者联合采用新福菌素化疗和放疗进行治疗,观察两组患者肿瘤消退和出现毒副反应的情况。结果:治疗组患者治疗的总有效率为92%,对照组患者治疗的总有效率为60%。在分别使用50Gy和70Gy的剂量进行照射治疗时,治疗组患者肿瘤的消退率为84%、92%,对照组患者肿瘤的消退率为40%、64%,治疗组患者出现白细胞指数下降、血小板指数下降、血红蛋白指数下降和腹泻的几率分别为48%、56%、48%和20%。对照组患者发生白细胞指数下降、血小板指数下降、血红蛋白指数下降和腹泻的几率分别为92%、72%、64%和32%。结论:联合使用新福菌素化疗和放疗可以提高治疗晚期鼻咽癌患者的总有效率,加快肿瘤组织消退的速度,减轻毒副反应,较适合晚期鼻咽癌患者使用。Objective To observe the therapeutic effect and adverse reaction of sinoactinomycin-chemotherapy with radiotherapy for patients with advanced nasopharyngeal carcinoma. Methods From April 2011-April 2012, 50 patients were pathology confirmed to be nasopharyngeal carcinoma after randomly divided into the control group and treatment group. There are 25 cases in radiotherapy group, the other 25 cases was the experiment group. After the end of treatment, the tumor and its side-effects were observed. Results From the short-term curative effect, the total effective rate of treatment group was 92%, while the control group was only 60%; Using 50Gy and 70Gy dose exposure, the tumor regression rate of treatment group was 84% and 92%, respectively;while the control group was only 40% and 64%. In treatment group, side effects such as decrease in white blood cells, platelets, hemoglobin and diarrhea, which occurred, respectively, 48%,56%, 48% and 20%, while the occurrence rate in the control group was 92%, 72%, 64% and 32%, respectively. Conclusion Concurrent sinoactinomycin-chemotherapy with radiotherapy could enhance the total effective rate, speed up the tumor regression rate, reduce the side effects and it's suitable for application in advanced nasopharyngeal carcinoma.

关 键 词：新福菌素 晚期鼻咽癌 放射治疗 

分 类 号：R739.63[医药卫生—肿瘤]