胃肠道间质瘤60例临床及病理分析  

作　　者：夏仙根[1] 吕春燕[1] 苏旭[1] 

机构地区：[1]成都市第五人民医院,四川成都610000

出　　处：《求医问药（下半月）》2013年第2期240-241,共2页Seek Medical and Ask The Medicine

摘　　要：目的探讨胃肠道间质瘤(GISTs)的临床病理学特征。方法回顾性分析60例胃肠道间质瘤的临床特征、病理大体及镜下特点、免疫表型、恶性诊断指标,并对患者进行随访。结果 60例GISTs中男性31例,女性29例,平均年龄55.6岁。腹痛和血便是GISTs常见临床表现,发生于胃35例,小肠19例,直肠4例,结肠2例,9例复发或转移。大体肿块直径2-15cm;镜下形态学以梭形细胞为主,少许细胞上皮样或两种细胞混合型。免疫表型Vimentin100%、DOG193.33%、CD11790%、CD3488.33%、S10031.67%、actin26.7%、SMA23.33%、CK0%,Ki-67≤1%39例、2%-5%12例、5%-10%7例、>10%2例。结论 GISTs是最常见的胃肠道间叶源性肿瘤,镜下形态学以梭形细胞为主,无特异性,诊断与鉴别必需依据免疫表型,恶性诊断指标需综合考虑。Objectives Study of gastrointestinal stromal tumors(GISTs) of the clinical and pathological features.Methods A retrospective analysis of 60 cases of gastrointestinal stromal tumors:clinical features,pathological and endoscopic features,immunophenotype,malignant diagnosis index,and the patients were followed up.Results In 60 GISTs patients,31 were male,29 female,mean age 55.6 years.Abdominal pain and bloody stool is a common clinical manifestation of GISTs,whice occurs in the stomach in 35 cases,19 cases in small intestine,4 cases in rectum,colon in 2 cases,9 cases of whice recurrence or metastasis.Gross mass with a diameter of 2-15cm;microscopic morphology with spindle-shaped cells,some cell epithelioid or two cell hybrid.Immune phenotypes of Vimentin 100%,DOG1 93.33%,CD117 90%,CD34 88.33%,S100 31.67%,actin 26.7%,SMA 23.33%,CK 0%,Ki-67 ≤1% 39 cases,2%-5%12 cases,5%-10%7 cases,>10%2 cases.Conclusion GISTs is one of the most common gastrointestinal mesenchymal tumor,endoscopic morphology with spindle-shaped cells,are nonspecific,diagnosis and differential diagnosis must be based on immune phenotype,malignant diagnosis index should be considered.

关 键 词：胃肠道间质瘤 临床及病理学特征 免疫表型 恶性指标 

分 类 号：R735.2[医药卫生—肿瘤] R735.3[医药卫生—临床医学]