Word of caution before implementing ketotifen for gastrointestinal transit improvement  

作　　者：Kostan W Reisinger Jacco J de Haan Marc H Schreinemacher 

机构地区：[1]Department of Surgery,Maastricht University Medical Center and NUTRIM School for Nutrition,Toxicology and Metabolism,Maastricht University

出　　处：《World Journal of Gastroenterology》2013年第27期4445-4446,共2页世界胃肠病学杂志（英文版）

摘　　要：The therapeutic potential of long-term ketotifen in irritable bowel syndrome and postoperative ileus is currently under investigation. Ambiguous results of prolonged postoperative ketotifen use on gastrointestinal passage have been found. The current data point at a hampered gastrointestinal transit after prolonged postoperative ketotifen use in a rodent ileus induction model. Therefore, caution should be taken when administering ketotifen in the perioperative phase.The therapeutic potential of long-term ketotifen in irritable bowel syndrome and postoperative ileus is currently under investigation. Ambiguous results of prolonged postoperative ketotifen use on gastrointestinal passage have been found. The current data point at a hampered gastrointestinal transit after prolonged postoperative ketotifen use in a rodent ileus induction model. Therefore, caution should be taken when administering ketotifen in the perioperative phase.

关 键 词：KETOTIFEN GASTROINTESTINAL TRANSIT POSTOPERATIVE ILEUS 

分 类 号：R573[医药卫生—消化系统]