Tolerance and chimerism and allogeneic bone marrow/stem cell transplantation in liver transplantation  

作　　者：Sheng-Li Wu Cheng-En Pan 

机构地区：[1]Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University

出　　处：《World Journal of Gastroenterology》2013年第36期5981-5987,共7页世界胃肠病学杂志（英文版）

摘　　要：The liver has particular tolerogenic properties that allow its spontaneous acceptance in some animal species.Liver structure is considered to favor a tolerogenic environment.The peripheral tolerance mechanisms also play a role in spontaneous tolerance to liver graft.In a clinical setting,the main challenge nowadays facing liver transplantation is minimization of immunosuppression with the goal of donor-specific tolerance.Mechanisms involved in tolerance to transplanted organs are complex and partly unknown.A significant mechanism in tolerance induction is chimerism.Chimerism can be induced through transplantation of allogeneic donor bone marrow/stem cells under appropriate host conditioning.This review focuses on the tolerance mechanisms in liver transplantation and highlights the role of chimerism and allogeneic bone marrow/stem cell transplantation in tolerance development.The liver has particular tolerogenic properties that allow its spontaneous acceptance in some animal species. Liver structure is considered to favor a tolerogenic environment. The peripheral tolerance mechanisms also play a role in spontaneous tolerance to liver graft. In a clinical setting, the main challenge nowadays facing liver transplantation is minimization of immunosuppression with the goal of donor-specific tolerance. Mechanisms involved in tolerance to transplanted organs are complex and partly unknown. A significant mechanism in tolerance induction is chimerism. Chimerism can be induced through transplantation of allogeneic donor bone marrow/stem cells under appropriate host conditioning. This review focuses on the tolerance mechanisms in liver transplantation and highlights the role of chimerism and allogeneic bone marrow/stem cell transplantation in tolerance development.

关 键 词：IMMUNOTOLERANCE CHIMERISM Bone MARROW TRANSPLANTATION Stem cell TRANSPLANTATION Liver TRANSPLANTATION 

分 类 号：R657.3[医药卫生—外科学]