IMMUNOTOLERANCE

作品数：15被引量：83H指数：5
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相关领域：医药卫生更多>>
相关作者：徐宁安更多>>
相关机构：浙江大学医学院附属第一医院中南大学更多>>
相关期刊：《Cellular & Molecular Immunology》《Virologica Sinica》《World Journal of Gastroenterology》《Chinese Medical Journal》更多>>
相关基金：国家自然科学基金浙江省科技厅资助项目广东省自然科学基金更多>>
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Transferrin Is Up-Regulated by Microbes and Acts as a Negative Regulator of Immunity to Induce Intestinal Immunotolerance
《Research》2024年第3期761-774,共14页Xiaopeng Tang Mingqian Fang Ruomei Cheng Junkun Niu Xiaoshan Huang Kuanhong Xu Gan Wang Yang Sun Zhiyi Liao Zhiye Zhang James Mwangi Qiumin Lu Aili Wang Longbao Lv Chao Liu Yinglei Miao Ren Lai 
the National Key Research and Development Program of China(2022YFF1301601);the Ministry of Science and Technology of China(2018YFA0801403 and 2022YFC2105003);the National Science Foundation of China(31930015,32100907,U2002219,and 32371162);the Chinese Academy of Sciences(KFJ-BRP-008 and SAJC202103);Yunnan Province(202003AD150008,202202AA100002 and 202301AS070074);the Kunming Science and Technology Bureau(2022SCP007);the New Cornerstone Investigator Program from Shenzhen New Cornerstone Science Foundation,Excellent Young Scientists Foundation of Shandong Province(ZR2023YQ025);the Frontiers Medical Center,Tianfu Jincheng Laboratory Foundation(TFJC2023010007);the PI Project of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(GML2021GD0807).
Cross-talks (e.g., host-driven iron withdrawal and microbial iron uptake between host gastrointestinal tract and commensal microbes) regulate immunotolerance and intestinal homeostasis. However, underlying mechanisms ...
关键词：IMPAIRED IMMUNITY tolerance 
Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A_(2A/2B)receptors in tolerogenic dendritic cells被引量：3
《Acta Pharmaceutica Sinica B》2023年第6期2778-2794,共17页Gaona Shi Yu Zhou Wenshuai Liu Chengjuan Chen Yazi Wei Xinlong Yan Lei Wu Weiwei Wang Lan Sun Tiantai Zhang 
supported by the National Key R&D Program of China(No.2020YFA0908004);the National Natural Science Foundation of China(Nos.82293684,82293680,82273936,82273929);CAMS Innovation Fund for Medical Science(No.2021-I2M-1-028,2022-I2M-2-002,2022-I2M-1-014,China);Natural Science Fund for Distinguished Young Scholars of Tianjin(No.21JCJQJC00020,China)。
Tolerogenic dendritic cells(tol DCs)facilitate the suppression of autoimmune responses by differentiating regulatory T cells(Treg).The dysfunction of immunotolerance results in the development of autoimmune diseases,s...
关键词：Mesenchymal stem cells Alginate hydrogel Tolerogenic dendritic cells IMMUNOTOLERANCE Adenosine A_(2A/2B)receptor CD39/CD73 Treg Rheumatoid arthritis 
Emerging role of miRNAs,lncRNAs,and circRNAs in pregnancy-associated diseases
《Chinese Medical Journal》2023年第11期1300-1310,共11页Xiaoxiao Fu Yuling Li Zhen Zhang Bin Wang Ran Wei Chu Chu Ke Xu Lihua Li Yonglin Liu Xia Li 
Natural Science Foundation of China(No.81873337);Natural Science Foundation of Shandong Province(No.ZR2019MH039);Central Government Guides Local Science and Technology Development Fund Projects of Shandong Province(No.YDZX20203700001407);Research Leader Studio Project of Jinan Science and Technology Bureau(No.2020GXRC050);Taishan Scholars(No.Tsqn201812125)
Accumulating studies have demonstrated that non-coding RNAs(ncRNAs),functioning as important regulators of transcription and translation,are involved in the establishment and maintenance of pregnancy,especially the ma...
关键词：Non-coding RNAs PREGNANCY Pregnancy-associated diseases Maternal-fetal interface IMMUNOTOLERANCE 
Continuous activation of polymorphonuclear myeloid-derived suppressor cells during pregnancy is critical for fetal development被引量：3
《Cellular & Molecular Immunology》2021年第7期1692-1707,共16页Mengyu Shi Ziyang Chen Meiqi Chen Jingping Liu Jing Li Zhe Xing Xiaogang Zhang Shuaijun Lv Xinyao Li Shaowen Zuo Shi Feng Ying Lin Gang Xiao Liping Wang Yumei He 
supported by grants from the following institutions:the High-level Talent Start-up Funding of Southern Medical University;the National Natural Science Foundation of China(grant numbers:31700061,81971420 and 81991511);the Guangdong Special Support Program for Youth Science and Technology Innovation Talents(grant number:2019TQ05Y585);the National Natural Science Foundation of Guangdong(grant number:2019A1515011435);the Science and Technology Program of Guangzhou(grant number:201904010073).
The maternal immune system is vital in maintaining immunotolerance to the semiallogeneic fetus for a successful pregnancy.Although studies have shown that myeloid-derived suppressor cells(MDSCs)play an important role ...
关键词：Polymorphonuclear myeloid-derived suppressor cells Class E scavenger receptor 1 IMMUNOTOLERANCE 
Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics被引量：17
《World Journal of Gastroenterology》2014年第42期15632-15649,共18页Julio Plaza-Diaz Carolina Gomez-Llorente Luis Fontana Angel Gil 
The potential for the positive manipulation of the gut microbiome through the introduction of beneficial microbes, as also known as probiotics, is currently an active area of investigation. The FAO/WHO define probioti...
关键词：Gene expression IMMUNITY IMMUNOTOLERANCE Inflammation Microbiota PROBIOTICS GUT LIVER 
Unusual outcome of in utero infection and subsequent postnatal super-infection with different PCV2b strains
《Virologica Sinica》2014年第3期176-182,共7页Dipongkor Saha Uladzimir U.Karniychuk Liping Huang Marc Geldhof Merijn Vanhee David J.Lefebvre Peter Meerts Richard Ducatelle Jan V.Doorsselaere Hans J.Nauwynck 
VC2002, isolated from postweaning multisystemic wasting syndrome(PMWS)-affected pig, is a mixture of two porcine circovirus genotype 2b(PCV2b) viruses, K2 and K39. Preliminary experiments disclosed short-term adverse ...
关键词：PCV2 immunotolerance PMWS porcine foetuses 
A mouse model for HBV immunotolerance and immunotherapy被引量：27
《Cellular & Molecular Immunology》2014年第1期71-78,共8页Dan Yang Longchao Liu Danming Zhu Hua Peng Lishan Su Yang-Xin Fu Liguo Zhang 
Lack of an appropriate small animal model remains a major hurdle for studying the immunotolerance and immunopathogenesis induced by hepatitis B virus （HBV） infection. In this study, we report a mouse model with sust...
关键词：AAV vector HBV IMMUNOTHERAPY IMMUNOTOLERANCE mouse model 
Tolerance and chimerism and allogeneic bone marrow/stem cell transplantation in liver transplantation被引量：3
《World Journal of Gastroenterology》2013年第36期5981-5987,共7页Sheng-Li Wu Cheng-En Pan 
The liver has particular tolerogenic properties that allow its spontaneous acceptance in some animal species.Liver structure is considered to favor a tolerogenic environment.The peripheral tolerance mechanisms also pl...
关键词：IMMUNOTOLERANCE CHIMERISM Bone MARROW TRANSPLANTATION Stem cell TRANSPLANTATION Liver TRANSPLANTATION 
NK cells in immunotolerant organs被引量：14
《Cellular & Molecular Immunology》2013年第3期202-212,共11页Haoyu Sun Cheng Sun Zhigang Tian Weihua Xiao 
Organs such as the liver, uterus and lung possess hallmark immunotolerant features, making these organs important for sustaining self-homeostasis. These organs contain a relatively large amount of negative regulatory ...
关键词：IMMUNOTOLERANCE LIVER LUNG natural killer cell UTERUS 
Presence of donor-and-recipient-derived DNA microchimerism in the cell-free blood samples of renal transplantation recipients associates with the acceptance of transplanted kidneys
《Asian Journal of Andrology》2006年第4期477-482,517,共6页Yao-Wen Fu Wei-Gang Wang Hong-Lan Zhou Lu Cai 
Aim:To examine whether the existence of the donor-and recipient-derived DNA chimerism in recipient's plasma can be a predictive marker for the status of transplanted organ.Methods:One hundred and twenty-six female pat...
关键词：renal transplantation donor-and-recipient-derived DNA microchimerism IMMUNOTOLERANCE renal rejection 
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