贵州地区762例肝癌患者的危险因素分析  

A case-control study on the risk factors of hepatocellular carcinoma in Guizhou Province

作　　者：赵雪珂[1] 程明亮[1] 张权[1] 陈莎莎[1] 谭家武[1] 王文志[1] 罗新华[2] 刘三都 林世德[4] 

机构地区：[1]550004,贵阳医学院附属医院感染科 [2]贵州省人民医院感染科 [3]黔南州人民医院感染科 [4]遵义医学院附属医院感染科

出　　处：《中华肝脏病杂志》2014年第1期-,共5页Chinese Journal of Hepatology

基　　金：国家重点基础研究发展计划(973)专项课题，贵州省科技计划课题

摘　　要：目的 探讨贵州地区人群原发性肝癌(HCC)的危险因素.方法 对贵州地区9家医院确诊的762例肝癌患者为观察组,798例非肿瘤居民为对照组,采用调查表进行问卷调查,由专人负责调查.调查内容包括年龄、性别、民族、居住地区、文化程度、经济状况、体质量指数,HCC家族史,HBV、HCV感染史,常进食腌制、霉变食物史,吸烟史、饮酒史,有无糖尿病、非酒精性脂肪肝、酒精性肝病及其他既往病史等.采用成组病例对照研究,通过非条件logistic回归分析及分层分析. 结果 观察组吸烟者210例(27.6％)、非酒精性脂肪肝336例(44.1％)、酒精性肝病245例(32.2％)、HCC家族史141例(16.5％)、饮酒者300例(39.4％)、HBV感染者436例(57.2％)、经常进食腌制、霉变食物290例(38.1％)、5年前经济状况好152例(19.9％)；对照组,吸烟者116例(14.5％)、非酒精性脂肪肝160例(20.1％)、酒精性肝病101例(12.7％)、HCC家族史40例(5.0％)、饮酒者180例(22.6％)、HBV感染82例(10.3％)、经常进食腌制、霉变食物225例(28.2％)、5年前经济状况好352例(44.1％).其OR值分别为3.520、2.464、4.330、2.219、2.451、19.245、6.212、0.174,P值均＜0.01,差异有统计学意义. 结论 HBV感染、经常食用腌制、霉变食物为贵州人群肝癌常见的危险因素,吸烟及过度饮酒也可增加患肝癌的风险.Objective To determine the risk factor of HCC in Guizhou.Methods A group case-control study design was conducted between 762 cases and 798 controls in Guizhou province.The main related-factors were analyzed with unconditional logistic regression model and evaluated by odds ratio (OR) and 95％ confidence interval (95％ CI).Results There are significant differences between cases and controls in regarding to cigarette smoking 210(27.6％),non-alcoholic fatty liver disease 336(44.1％),alcoholic liver disease 245(32.2％),family history of HCC 141(16.5％),alcohol consumption 300(39.4％),HBV infection 436(57.2％),pickled food 290(38.1％),and economic status 5 years ago 420(55.1％) in cases,and cigarette smoking 116(14.5 ％),non-alcoholic fatty liver disease 160(20.1％),alcoholic liver disease 101 (12.7％),family history of HCC 40(5.0％),alcohol consumption 180(22.6％),HBV infection 82(10.3％),pickled food 225(28.2％),and economic status 5 years ago 647(81.1％) in controls,with OR of each variable was 3.520,2.464,4.330,2.219,2.451,19.245,6.212,0.174 respectively,P＜ 0.01.Conclusion HBV infection and pickled food were the most common risks for HCC in Guizhou.Alcohol consumption excessively and cigarette smoking may increase the risk too.

关 键 词：癌 肝细胞 临床研究 危险因素 肝炎病毒 乙型 饮酒 

分 类 号：R735.7[医药卫生—肿瘤]