胆管癌组织中KAI1/CD82和层黏素受体的关系  

Correlation of KAI1/CD82 and laminin receptor in cholangiocarcinoma

作　　者：邓小明[1] 王曙光[1] 高占峰[1] 李天宇[1] 蒋卫伟[1] 

机构地区：[1]第三军医大学西南医院全军肝胆外科研究所,中国人民解放军西南肝胆外科医院,重庆,400038

出　　处：《中华消化外科杂志》2008年第5期-,共3页Chinese Journal of Digestive Surgery

摘　　要：目的 探讨肿瘤转移抑制基因KAI1/CD82和层黏素受体(laminin receptor,LNR)在胆管癌组织中的表达相关性及与胆管癌侵袭、转移的关系.方法 应用免疫组织化学方法检测和分析48例胆管癌组织中KAI1/CD82和LNR的表达,并探讨其和临床病理特征的关系.结果 KAI1/CD82的阳性表达率为31%(15/48),LNR的阳性表达率为54%(26/48).分化程度越高,KAI1/CD82阳性表达率越高(χ2=3.911,P<0.05),而LNR的阳性表达率则越低(χ2=6.970,P<0.05);KAI1/CD82在有淋巴结转移的阳性表达率较无淋巴结转移低(χ2=5.765,P<0.05),而LNR在有淋巴结转移的阳性表达率则较无淋巴结转移高(χ2=9.952,P<0.05).KAI1/CD82和LNR呈负相关(r=-0.462,P<0.01).结论 胆管癌组织中LNR的表达上调与KAI1/CD82表达减少或缺失有关,并且在胆管癌的侵袭、转移中起重要作用.Objective To investigate the correlation of the expression of KAI1/CD82 and laminin receptor (LNR) in cholangiocarcinoma, and study its role in the invasion and metastasis of cholangiocarcinoma. Methods The expressions of KAI1/CD82 and LNR in 48 cholangiocarcinoma tissue samples were detected by SP immunohistochemistry, and their relationships with clinicopathological factors were analyzed. Results The positive expression rates of KAI1/CD82 and LNR in cholangiocarcinoma were 31% (15/48) and 54% (26/48), respectively. In highly differentiated cholangiocarcinoma, the positive expression rate of KAI1/CD82 was high (χ2=3.911, P<0.05), while that of the LNR was low (χ2=6.970, P<0.05). The positive expression rate of KAI1/CD82 in cholangiocarcinoma with metastasis was significantly lower than that in cholangiocarcinoma without metastasis (χ2=5.765, P<0.05), while the positive expression rate of LNR in cholangiocarcinoma with metastasis was significantly higher than that in cholangiocarcinoma without metastasis (χ2= 9.952, P<0.05). The expression level of KAI1/CD82 was negatively correlated with that of the LNR ( r = -0.462, P < 0.01 ). Conclusions The up-regulated expression of LNR in cholangiocarcinoma correlates with the decreased expression of KAI1/CD82, and plays an important role in the invasion and metastasis of cholangio-carcinoma.

关 键 词：KAI1/CD82 层黏素受体 胆管肿瘤 转移 

分 类 号：R735.8[医药卫生—肿瘤]