伽玛刀剂量分割治疗脑深部胶质瘤的临床研究  

The clinical study of gamma knife in dose fraction treatment of brain gliomas

作　　者：闫平平[1] 张福成[1] 刘宝来[2] 

机构地区：[1]山西医科大学第三医院肿瘤治疗中心,太原,030053 [2]山西医科大学第二医院神经外科

出　　处：《肿瘤研究与临床》2007年第z1期-,共3页Cancer Research and Clinic

摘　　要：目的 探讨伽玛刀剂量分割治疗脑深部较大胶质瘤的临床疗效.方法 采用旋转式伽玛刀剂量分割治疗脑深部较大(直径＞3 cm)胶质瘤64例,均安装立体定位头架可重复配件,每天治疗1次,连续进行2～5 d,每次周边剂量5～10 Gy,每次治疗结束后摘取定位头架,下次治疗时重复原位安装.结果 治疗后3～15个月获得随访的57例患者中.完全缓解(CR)8例,部分缓解(PR)29例,总有效(CR+PR)率为64.9%,无变化(NC)14例,临床获益率(CBR)为83.4%,进展(PD)6例.脑水肿反应为治疗后的主要不良反应.结论 对于脑深部较大胶质瘤,伽玛刀剂量分割治疗近期疗效明确,可缓解症状,提高生活质量.Objective To investigate the dose fraction of gamma knife treatment brain deep larger glioma clinical efficacy.Methods To adopt rotating gamma knife in dose fraction treatment of brain deep larger(d＞3 cm),64 cases of gliomas,were installed stereotactic head frame can repeat accessories,for a day,for two consecutive days to five,each around 5-10 Gy for each treatment,fixed the first-place after the removal,the next treatment repeat.ReslIlts After 6 to 24 months of follow-up was 57 patients,complete response(CR)in 8 cases,partial response(PR)in 29 cases,the total efficiency of 64.9%,no change(NC)in 14 cases,clinical benefit rate of 83.4%,progressive disease(PD)in 6 cases.Brain edema response after treatment was the major side effects.Conclusion For deep larger brain glioma,dose fraction of gamma knife treatment was clearly effective recently,it could ease symptoms and improve quality of life.

关 键 词：胶质瘤 放射外科手术 

分 类 号：R739.41[医药卫生—肿瘤]