胃癌中上皮型钙黏附蛋白的表达及其与胃癌分化转移的关系  

Expression of E-cadhrein and its relationship with differentiation and metastasis in gastric cancer

作　　者：王培龙[1] 李建红[2] 郭建猛[3] 

机构地区：[1]长治医学院附属和济医院内镜科,046000 [2]长治医学院病理教研室 [3]长治医学院附属和济医院普外科,046000

出　　处：《肿瘤研究与临床》2008年第8期545-547,共3页Cancer Research and Clinic

摘　　要：目的 研究胃癌细胞上皮型钙黏附蛋白(E-Cad)表达及其与胃癌Lauren分型、分化程度、临床分期、浸润深度、淋巴结转移和远处转移的关系.方法 连续收集长治医学院附属和济医院胃癌切除术后组织标本80例,按照病理组织分型分为管状腺癌、黏液腺癌、髓样癌及弥漫型癌四组.应用免疫组织化学SP法进行E-Cad检测,对E-Cad表达阳性与胃癌的分化、转移等进行相关分析.结果 80例胃癌组织标本中E-Cad表达率为55.00%,E-Cad在胃癌组织中的表达与胃癌Lauren分型、分化程度、临床分期、浸润深度、淋巴结转移和远处转移显著相关(P＜0.05),而与患者性别、年龄、肿瘤大小等参数无相关性.E-Cad在有淋巴结转移的胃癌原发灶和转移淋巴结中的表达率分别为35.48%和32.26%.E-Cad的表达与有淋巴结转移的胃癌中的原发灶和转移淋巴结呈显著相关(r=0.4978,P＜0.05).结论 免疫组织化学观察发现具有侵袭性组织病理学特征的肿瘤常有E-Cad表达,E-Cad的表达与胃癌分化、侵袭转移密切相关.Objective To investigate the expression of E-cadherin(E-cad)and the relationship with the Lauren classification,the degree of histological differentiation,the clinical stage,the depth of invasion,lymph node metastasis and distant metastasis of gastric cancer. Methods 80 cases architecture of gastric cancer and normal tissue were collected.The expression level of E-cad in 80 cases of gastric carcinomas and their metastatic lymph node tissues were examined by immunohistochemical assays.Results The expression rate of E-cad in 80 cases of gastric carcinomas Was 55.00%.The expression level of E-cad was positively correlated with the Lauren classification,the degree of histological differentiation,the clinical stage,the depth of invasion,lymph node metastasis and distant metastasis(P＜0.05),but Was not correlated to patients sex,age and tumor size.The expression rates of E-cad in metastatic gastric carcinoma of primary lesions and lymph nodes metastasis were 35.48%and 32.26%. respectively. Furthermore, E-cad expression in metastatic gastric carcinoma was significandy correlated with primary lesions and lymph node memstasis(r=0.4978,P＜0.05).Conclusion The expression level of E-cad in gastric carcinoma Was closely correlated with the degree of tumor differentiation,infiltration and transferring.

关 键 词：胃肿瘤 钙黏着糖蛋白 细胞分化 肿瘤转移 

分 类 号：R735[医药卫生—肿瘤]