急性白血病患者化疗后CD+34细胞数量变化及其意义  

The study of clinical significance of CD+34 cell in the acute leukemia patients after chemotherapy

作　　者：杨恩芹[1] 刘加强[1] 李同英[1] 

机构地区：[1]山东省日照市人民医院血液科,276800

出　　处：《白血病．淋巴瘤》2008年第2期-,共3页Journal of Leukemia & Lymphoma

摘　　要：目的 探讨急性白血病(AL)患者化疗后CD+34细胞数量变化对粒细胞集落刺激因子(G-CSF)的应用和判断是否早期缓解的指导意义.方法 50例初发白血病患者化疗后于WBC最低点应用G-CSF,不同时间测定外周血WBC、中性粒细胞数(MNC)、Plt与CD+34细胞数量,并对它们的相关性进行研究.结果 化疗后极期CD+34细胞为(3.05±2.47)个/μl,与化疗前比较明显降低(P＜0.01),在恢复期显著增加,为(113.46±77.16)个/μl(P＜0.01).WBC、MNC、Plt数量变化与CD+34细胞数量呈显著正相关(r分别为0.970、0.837、0.850,P均＜0.01).当极期末WBC/CD+34＞400,能早期判断AL患者是否缓解,CD+34＜5/μl,可应用G-CSF,CD+34＞5/μl,停用G-CSF.结论 白血病患者化疗后监测CD+34细胞数量变化,对早期判断是否缓解和G-CSF的应用具有重要的指导意义.Objective To explore the clinical significance of the CD+34 cell variance to the application of G-CSF and early judgement of complete remission(CR)in the acute leukemia patients after chemotherapy.Methods G-CSF was applied in the lowest period of WBC in 50 acute leukemia patients after chemotherapy.WBC,MNC,Pit,CD+34 cell were detected in different time and the correlation was studied between them.Results The count of CD;4 cell decreased significantly in the end of the lowest period (3.05±2.47)/μ1,(P＜0.01)and increased significantly(113.46±77.16)/μl,(P＜0.01)in the recovering period.The count variance of WBC MNC and Plt has significant correlation compare with CD+34 cell(r=0.970,0.837,0.850,P＜0.01)in the lowest period,when WBC/CD+34＞ 400,the patient probably achieved CR,CD+34＜5/μl,G-CSF Can be used safely,however,CD+34＞5/μ1,G-CSF should be stopped.Conclusion To detect the count of CD+34 cell can provide many useful informations which can help us to judge the early CR and use the GCSF correctly.

关 键 词：白血病 粒细胞集落刺激因子 

分 类 号：R733.71[医药卫生—肿瘤]