Peripheral arterial disease, type 2 diabetes and postprandial lipidaemia: Is there a link?  

作　　者：Pedro Valdivielso José Ramírez-Bollero Carmen Pérez-López 

机构地区：[1]UGC de Medicina Interna, Hospital "Virgen de la Victoria" de Málaga y Departamento de Medicina y Dermatología Universidad de Málaga

出　　处：《World Journal of Diabetes》2014年第5期577-585,共9页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by Grant to Grupo CTS-159 of PAIDI(Plan Andaluz de Investigación,Desarrollo e Innovación) de la Junta de Andalucía

摘　　要：Peripheral arterial disease, manifested as intermittent claudication or critical ischaemia, or identified by an ankle/brachial index < 0.9, is present in at least one in every four patients with type 2 diabetes mellitus.Several reasons exist for peripheral arterial disease indiabetes. In addition to hyperglycaemia, smoking and hypertension, the dyslipidaemia that accompanies type2 diabetes and is characterised by increased triglyceride levels and reduced high-density lipoprotein cholesterol concentrations also seems to contribute to this association. Recent years have witnessed an increased interest in postprandial lipidaemia, as a result of various prospective studies showing that non-fasting triglycerides predict the onset of arteriosclerotic cardiovascular disease better than fasting measurements do. Additionally,the use of certain specific postprandial particle markers,such as apolipoprotein B-48, makes it easier and more simple to approach the postprandial phenomenon. Despite this, only a few studies have evaluated the role of postprandial triglycerides in the development of peripheral arterial disease and type 2 diabetes. The purpose of this review is to examine the epidemiology and risk factors of peripheral arterial disease in type 2 diabetes, focusing on the role of postprandial triglycerides and particles.Peripheral arterial disease, manifested as intermittent claudication or critical ischaemia, or identified by an ankle/brachial index &lt; 0.9, is present in at least one in every four patients with type 2 diabetes mellitus.Several reasons exist for peripheral arterial disease indiabetes. In addition to hyperglycaemia, smoking and hypertension, the dyslipidaemia that accompanies type2 diabetes and is characterised by increased triglyceride levels and reduced high-density lipoprotein cholesterol concentrations also seems to contribute to this association. Recent years have witnessed an increased interest in postprandial lipidaemia, as a result of various prospective studies showing that non-fasting triglycerides predict the onset of arteriosclerotic cardiovascular disease better than fasting measurements do. Additionally,the use of certain specific postprandial particle markers,such as apolipoprotein B-48, makes it easier and more simple to approach the postprandial phenomenon. Despite this, only a few studies have evaluated the role of postprandial triglycerides in the development of peripheral arterial disease and type 2 diabetes. The purpose of this review is to examine the epidemiology and risk factors of peripheral arterial disease in type 2 diabetes, focusing on the role of postprandial triglycerides and particles.

关 键 词：Peripheral ARTERIAL disease Type 2 diabetes POSTPRANDIAL lipidaemia APOLIPOPROTEIN B-48 Anklebrachial index Non-fasting TRIGLYCERIDES 

分 类 号：R587.1[医药卫生—内分泌] R543.5[医药卫生—内科学]