引起阿尔茨海默病的γ-分泌酶作用机制  

The mechanism of γ-secretase cause Alzheimer’s Disease

作　　者：张锦巍[1] 井丽娟[1] 孙亚平[1] 李聪[1] 董贵成[1] 

机构地区：[1]内蒙古科技大学包头师范学院,中国内蒙古包头市014030

出　　处：《生物技术世界》2012年第12期8-10,共3页Biotech World

基　　金：国家自然科学基金项目(30960334);内蒙古自然科学基金项目(2009BS1105);"2009年教育部新;世纪优秀人才支持计划"(NCET-09-0857)

摘　　要：γ-分泌酶剪切C99形成的Aβ在脑中的聚集认为是阿尔茨海默病的元凶,.GXGD结构域",含水腔隙"的发现使得对γ-分泌酶有了进一步认识。本文对γ-分泌酶的结构、作用机制及其抑制剂的研究做综述。β-amyloid concentration in the brain is considered a major cause of Alzheimer’s Disease. Aβ42,less soluble,is generated via the cleavage of β-amyloid protein precursorbyγ-secretase.New research confirms that a GXGD motif around the activesites of PS,it is important for theγ-secretase- cleavage Because the water-containing-cavityexist,γ-secretase made the intramembrane cleavage in the highlyhydrophobic environment possible.The potential target is theγ-secretase of Alzheimer’s Disease. This review focuses on the Recent studies on structure,mechanism and inhibitors ofγ-secretase

关 键 词：阿尔茨海默病 Γ-分泌酶 GXGD结构域 含水腔隙 Γ-分泌酶抑制剂 

分 类 号：R749.16[医药卫生—神经病学与精神病学]