Drug interaction presenting as acute abdomen  

作　　者：Rajesh Pendlimari Rajeswari Anaparthy Aravind Sugumar 

机构地区：[1]Division of Colon & Rectal Surgery Mayo Clinic [2]Division of Internal Medicine Mayo Clinic [3]Division of Gastroenterology & Hepatology Division of Gastroenterology & Hepatology Mayo Clinic

出　　处：《World Journal of Gastrointestinal Pharmacology and Therapeutics》2010年第1期40-42,共3页世界胃肠药理与治疗学杂志（英文版）（电子版）

摘　　要：Warfarin is the most common oral anticoagulant prescribed around the world. Adverse drug interactions with warfarin are a huge problem especially in the elderly and in patients who take multiple medications. Most adverse drug interactions involve concomitantly prescribed oral or intravenous medications. Occasionally, topical or mucosally absorbed drugs can interact, leading to fluctuations in warfarin levels with adverse consequences. In this case report, we describe a case of intestinal intramural hematoma, a rare but known consequence of a supra therapeutic international normalized ratio (INR). The supra therapeutic INR was a consequence of mucosally absorbed miconazole, prescribed for vaginal candidiasis. We wish to highlight this rare and potentially fatal drug interaction, along with the need for frequent INR monitoring when new drugs are added or removed in patients taking warfarin.Warfarin is the most common oral anticoagulant prescribed around the world. Adverse drug interactions with warfarin are a huge problem especially in the elderly and in patients who take multiple medications. Most adverse drug interactions involve concomitantly prescribed oral or intravenous medications. Occasionally, topical or mucosally absorbed drugs can interact, leading to fluctuations in warfarin levels with adverse consequences. In this case report, we describe a case of intestinal intramural hematoma, a rare but known consequence of a supra therapeutic international normalized ratio (INR). The supra therapeutic INR was a consequence of mucosally absorbed miconazole, prescribed for vaginal candidiasis. We wish to highlight this rare and potentially fatal drug interaction, along with the need for frequent INR monitoring when new drugs are added or removed in patients taking warfarin.

关 键 词：WARFARIN INTRAMURAL HEMATOMA MICONAZOLE Drug interactions International normalized ratio Supra THERAPEUTIC 

分 类 号：R656.1[医药卫生—急诊医学]