Effect of anesthetics on gastric damage using two models of portal hypertension  

作　　者：Paula RS Camara Gisele P Moi José Geraldo P Ferraz José Murilo R Zeitune 

机构地区：[1]UNIVAG,University Center of Várzea Grande [2]Division of Gastroenterology,Faculty of Medicine,State University of Campinas [3]Biochemistry Laboratory,Dental School of Piracicaba,State University of Campinas [4]Division of Gastroenterology,Faculty of Medicine,University of Calgary

出　　处：《World Journal of Gastrointestinal Pharmacology and Therapeutics》2010年第4期81-86,共6页世界胃肠药理与治疗学杂志（英文版）（电子版）

基　　金：Supported by a Doctoral Grant from the Fundao de Amparo à Pesquisa do Estado do So Paulo(FAPESP),Brazil

摘　　要：AIM:To investigate the effect of sodium pentobarbitone(SP) or ketamine/xylazine(KX) anesthetics on acute gastric injury.METHODS:Portal hypertension was induced by bile duct ligation(BDL) or portal vein stenosis(PVS).Ethanol(EtOH)-induced gastric damage was assessed using ex vivo gastric chamber experiments.Gastric blood flow(GBF) was also measured by laser doppler flowmetry.RESULTS:EtOH-induced gastric damage was reduced in BDL rats under KX anesthesia in comparison to those under SP anesthesia.GBF dysfunction in fasted BDL rats was partially restored under KX anesthesia.In contrast,in fasted PVS rats,EtOH-induced gastric damage was increased under KX anesthesia while GBF was reduced.CONCLUSION:The use of KX anesthesia in experimental procedures involving cirrhotic rats(but not those with pure portal hypertension) is preferable to SP anesthesia.AIM: To investigate the effect of sodium pentobarbitone (SP) or ketamine/xylazine (KX) anesthetics on acute gastric injury.METHODS: Portal hypertension was induced by bile duct ligation (BDL) or portal vein stenosis (PVS). Ethanol (EtOH)-induced gastric damage was assessed using ex vivo gastric chamber experiments. Gastric blood flow (GBF) was also measured by laser doppler flowmetry.RESULTS: EtOH-induced gastric damage was reduced in BDL rats under KX anesthesia in comparison to those under SP anesthesia. GBF dysfunction in fasted BDL rats was partially restored under KX anesthesia. In contrast, in fasted PVS rats, EtOH-induced gastric damage was increased under KX anesthesia while GBF was reduced.CONCLUSION: The use of KX anesthesia in experimental procedures involving cirrhotic rats (but not those with pure portal hypertension) is preferable to SP anesthesia.

关 键 词：Sodium pentobarbitone PORTAL hypertension CIRRHOSIS GASTRIC damage Ketamine/xylazine 

分 类 号：R614[医药卫生—麻醉学]