海马突触可塑性与创伤后应激障碍(PTSD)相关研究  

Research on Hippocampal Synaptic Plasticity and Traumatic Stress Disorder(PTSD)

作　　者：李航[1] 钟志鸿[1] 杨进[1] 董靖[1] 

机构地区：[1]西北大学生命科学学院,西安710069

出　　处：《基因组学与应用生物学》2015年第3期658-662,共5页Genomics and Applied Biology

基　　金：国家自然科学基金委基地能力提高项目(J1210063)资助

摘　　要：创伤后应激障碍(post-traumatic stress disorder,PTSD)是指遭受危险性和灾难性的精神创伤后的一种非正常的精神障碍性疾病。有调查显示大约有60.7%的男性和51.2%的女性在他们的一生中至少会经历一次创伤事件,而女性PTSD的发病率显著高于男性。PTSD给患者本身,以及家庭和社会的发展都带来严重的影响。因此,对PTSD的研究有着重要的意义。研究表明海马,杏仁核等脑区在恐惧形成中起着重要的作用。本文主要介绍与PTSD发病有关的相关因素外,还着重介绍LTP(long-term potentiation,LTP)在PTSD导致的海马可塑性变化中的作用,以及组胺,水孔道蛋白-4,成纤维因子2等因素在突触可塑性变化中的作用,为PTSD的日后研究提供有价值的线索。Post-traumatic stress disorder(PTSD) is a mental abnormality resulting from disastrous, psychic trauma.About 60.7 percent of men and 51.2 percent of women in their lifetime will experience at least one traumatic event, while the incidence of PTSD in women is significantly higher than that in men. In this regard, it is vital to investigate PTSD as it exerts serious impact on PTSD patients the homostasis and advance of households and society. Studies have shown that brain regions like the hippocampus, amygdala play important roles in the formation of fear. This paper mainly describes the factors regarding the pathogenesis of PTSD, especially the function of LTP(long-term potentiation, LTP) in hippocampal plasticity caused by PTSD, as well as the functions of histamine, water channel protein-4, fibroblast growth factor 2 and other factors in synaptic plasticity, which might provide valuable clues for the study of PTSD in the near future.

关 键 词：创伤后应激障碍 突触可塑性 长时程增强 

分 类 号：R749.5[医药卫生—神经病学与精神病学]