食管胃连接部小细胞癌13例临床病理分析  

Clinical analysis of 13 cases with esophago-gastric junction small cell carcinoma

作　　者：刘昊[1] 王旭东[1] 

机构地区：[1]吉林大学第二附属医院胃肠与营养外科,吉林130000

出　　处：《消化肿瘤杂志（电子版）》2013年第4期220-224,共5页Journal of Digestive Oncology(Electronic Version)

摘　　要：目的分析食管胃连接部小细胞癌的临床特点,结合文献总结其诊断及治疗方法。方法回顾性分析我科室收治的13例经病理证实的食管胃连接部小细胞癌患者的临床及病理资料,复习国内外报道的肺外小细胞癌的临床资料,总结其诊断及治疗。结果本组13例患者,男性12例,女性1例,平均年龄65.5岁(46~77岁)。4例患者术前确诊,9例术前存在误诊。12例行手术治疗,其中11例接受术后化疗,4例接受术后放疗。本组13例全部获得随访,2例术后生存时间超过40个月,1、3和5年的生存率分别为58.3%、37.5%、16.7%,中位生存期为14.0个月。淋巴结转移、TNM分期晚、广泛期是肿瘤患者预后不良的影响因素。结论食管胃连接部小细胞癌发病率低,其临床病理特点及生存预后特别,应视为一种特殊的组织学类型。Objective To analyze the clinicopathological and prognostic data of esophago-gastric junction small cell carcinoma(EGJSCC),and generalize its diagnosis, treatment and prognosis with literature review. Methods Clinicopathological and prognostic data of 13 patients with EGJSCC(confirmed by pathology)who received treatment from Janurary 2001 to May 2012 in our hospital were retrospectively analyzed.Results EGJSCC patients included 12 male and 1 female patients,with 65.6 years old on average, ranging from 46 to 77. Only 4 patients were diagnosed by preoperative endoscopic biopsy, and 9 cases were misdiagnosed. Twelve patients received radical operation and 11 of them received postoperative adjuvant chemotherapy, 4 received postoperative radiotherapy. The median survival time of the patients was 13.5months. The 1,3,5-year overall survival rates were 58.3%,37.5% and 16.7% respectively. Lymph node metastasis, advanced TNM stage and extensive stage were influencing factors for poor prognosis. Conclusions The incidence of EGJSCC is low. EGJSCC should be considered as a special histological type for its special clinicopathological features and prognostic outcome.

关 键 词：胃食管连接部 肺外小细胞癌 临床病理 预后 

分 类 号：R735.1[医药卫生—肿瘤]