胃食管反流病与幽门螺杆菌相关性研究  

The relationship between gastroesophageal reflux disease and Helicobacter pylori infection

作　　者：李强[1] 薛鸿鹏[1] 徐晓红[1] 朱春兰[1] 陆以霞[1] 祝喜萍[1] 

机构地区：[1]黑龙江省医院附属消化病院,哈尔滨市150001

出　　处：《中华胃肠内镜电子杂志》2015年第1期31-33,共3页Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition)

摘　　要：目的探讨胃食管反流病(GERD)与幽门螺杆菌(Hp)感染的关系。方法选取2010年8月至2012年10月黑龙江省医院附属消化病医院消化科GERD患者80例,进行胃镜检查及24 h食管pH值监测,按照內镜下有无食管黏膜破损分为非糜烂性反流病(NERD)50例,反流性食管炎(RE)30例,并选取同期就诊的100例慢性浅表性胃炎(CSG)为对照组,分别比较三组Hp感染率。结果NERD组Hp感染率38.0%,RE组Hp感染率为36.7%,CSG组Hp感染率为56%,NERD组及RE组Hp感染率明显低于对照组(P<0.05);NERD组及RE组Hp感染率无显著性差异(P>0.05)。结论Hp感染可能对GERD发生有一定保护作用;造成GERD不同发生机制不同的主要原因并非Hp感染。Objective To investigate the relationship between gastroesophageal reflux disease (NERD) and Helicobacter Pylori ( Hp) infection.Methods From August 2010 to October 2012 80 Patients ( Depantment of Gastroenterology .Gastroenterology Hospital Affiliated to Heilongjiang Provincial Hospital) with gastroesophageal reflux disease ( GERD) were selected, 50 patients with gastroscopy and esophageal 24-hour pH monitoring, patients with NERD, 30 patients with chronic superficial gastritis (CSG) were selected as the control groups , and three patients with Hp infection rate were compared with 100 patients with chronic superficial gastritis ( RE) .Results The Hp infection rate in NERD group was 38%, 36.7%in RE group, 56%in CSG group;Hp infection rates in and RE groups were significantly lower than that in the control group (P<0.05), NERD had no significant difference retween NERD and RE groups (P>0.05).Conclusion Hp infection might have some protective effects on NERD , and Hp infection was not the main reason for the difference of NERD and RE .

关 键 词：胃食管反流 幽门螺杆菌 食管pH检测 

分 类 号：R571[医药卫生—消化系统] R573[医药卫生—内科学]