MMP_9和CD_(44V6)表达与大肠腺癌浸润转移的关系  

The relationship between the expression of MMP_9 and CD_(44V6) and the invasion and metastasis of large intestine adenocarcinoma

作　　者：钟良清[1] 罗爱华[1] 曾洲红[1] 朱秀梅[1] 罗卫[1] 

机构地区：[1]广东高州市人民医院病理科,525200

出　　处：《中国基层医药》2004年第5期575-576,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　探讨MMP9和CD44V6在大肠癌中的表达与大肠腺癌术后是否复发的关系。方法　应用免疫组化技术 ,检测 12 8例大肠腺癌组织中MMP9和CD44V6的表达。结果　 12 8例大肠腺癌中MMP9、CD44V6表达的阳性标记与大肠腺癌分级、浆膜浸润、淋巴结转移有相关性。结论　MMP9和CD44V6联合表达与大肠腺癌浸润转移密切相关。检测MMP9和CD44V6表达可作为判断大肠腺癌预后的客观指标。Objective To discuss the relationship between the expression of MMP 9 and CD 44V6 in the large intestine adenocarcinoma and the recurrence of large intestine adenocarcinoma.Methods The expression of MMP 9 and CD 44V6 in 128 cases of large intestine adenocarcinoma was detected immunohistochemically.Results The expression of MMP 9 and CD 44V6 was related to the grading,invasion and lymph node metastasis.Conclusion The combined expression of MMP 9 and CD 44V6 is associated with the invasion and metastasis of large intestine adenocarcinoma.The detection of MMP 9 and CD 44V6 can indicate the prognosis of large intestine adenocarcinoma.

关 键 词：MMP9 CD44V6 大肠腺癌 肿瘤浸润 肿瘤转移 检测 

分 类 号：R735.3[医药卫生—肿瘤]