不同治则方药对实验性血管性痴呆小鼠学习记忆行为的影响  

Effects of Different Therapeutic Principles and Prescriptions on the Learning and Memorizing Behavior of the Experimental Vascular Dementia Rat

作　　者：封银曼[1] 任小巧[1] 龙旭阳[1] 郑攀[1] 

机构地区：[1]河南中医学院,河南郑州450008

出　　处：《河南中医》2004年第5期23-26,共4页Henan Traditional Chinese Medicine

基　　金：河南省杰出青年基金资助项目 (0 1 1 2 0 0 1 30 0 )

摘　　要：目的 :研究不同治则方药对实验性血管性痴呆小鼠学习记忆行为的影响。方法 :采用双侧颈总动脉反复夹闭并降血压法造成小鼠实验性血管性痴呆模型 ,以跳台法和Merris水迷宫法测试小鼠的学习记忆行为能力。结果 :实验各中药组均能提高实验性血管性痴呆模型小鼠的学习记忆能力 ,其中以益气补肾祛瘀化痰组最为显著。结论 :提示精气亏虚、血瘀痰阻可能是血管性痴呆的基本病机 ,应当确立益气补肾。Purpose: To study the effects of different therapeutic principles and prescriptions on the learning and memorizing behavior of the experimental vascular dementia rat. Method: By repeatedly clipping to shut the bilateral common carotid artery and declining the blood pressure, an experimental vascular dementia rat model was made to test its learning and memorizing ability with diving platform method and water maze method. Result: The learning and memorizing ability of the experimental vascular rat model was improved in all the drug groups , and especially it was the most obvious for the group of supplementing qi to tonify the kidney and removing blood stasis and eliminating the phlegm. Conclusion: It is suggested that the deficiency of vital essence and blood stasis and phlegm stagnation may be the basic pathogenesis of vascular dementia, supplementing qi to tonify the kidney and removing blood stasis and eliminating the phlegm should be the fundamental therapeutic principles.

关 键 词：血管性痴呆 治则 方药 学习记忆能力 小鼠 

分 类 号：R743.9[医药卫生—神经病学与精神病学]