癫痫患者脑脊液细胞因子含量变化及其意义  

Change of cytokines levels in cerebrospinal fluid of epileptic patients and its significance

作　　者：许文华[1] 余峰[1] 任佰玲[1] 汪银洲[1] 

机构地区：[1]安徽省立医院神经内科,合肥230001

出　　处：《中国临床保健杂志》2004年第3期190-191,共2页Chinese Journal of Clinical Healthcare

摘　　要：目的　探讨癫痫患者脑脊液中细胞因子含量变化及其意义。方法　应用放射免疫法对 4 3例癫痫患者脑脊液中IL 2、IL 6、IL 8和TNF α含量进行了检测。结果　癫痫患者脑脊液中IL 2、IL 6、IL 8和TNF α含量明显高于对照组 (P <0 0 0 1～ 0 0 5 )。相关分析发现脑脊液中细胞因子含量与癫痫发作频率呈正相关。Objective To probe into the change of cytokines levels in cerebrospinal fluid of epileptic patients and its significance.Methods The cerebrospinal fluid levels of IL-2,IL-6,IL-8 and TNF-α in 43 epileptic patients and 32 controls were measured by radioimmunoassay.Results The mean IL-2,IL-6,IL-8 and TNF-α levels in epileptic patients were markedly higher than those of the controls(P<0.001～0.05).There was positive correlation between cytokines and epileptic frequency.Conclusion The results indicates that cytokines may play a role in the pathogenesis of epileptic patients.

关 键 词：癫痫 细胞因子 脑脊液 

分 类 号：R742.1[医药卫生—神经病学与精神病学]