Stability of Baicalin Aqueous Solution by Validated RP-HPLC  

黄芩苷水溶液的稳定性(英文)

作　　者：仇峰[1] 唐星[1] 何仲贵[1] 李好枝[1] 

机构地区：[1]沈阳药科大学药学院药剂系,沈阳110016

出　　处：《Journal of Chinese Pharmaceutical Sciences》2004年第2期134-137,共4页中国药学（英文版）

摘　　要：Aim In the present study a RP-HPLC method was developed and validated toinvestigate the stability of baicalin aqueous solution. Methods The influences of temperature and pHon the stability of baicalin aqueous solution were investigated by classic homoiothermicacceleration test, and the pH for the most stable solution was determined. Results The time whenbaicalin suffered 10% loss was found to be 18.1 h, and the degradation activation energy of baicalinwas 79.1 kJ·moL^(-1) . The pH at which baicalin is most stable is 4.28. Conclusion The temperatureshould be kept at a lower level and the pH should be adjusted to near that for the most stablesolution in the production of baicalin preparations.目的　采用RP HPLC法考察了黄芩苷水溶液的稳定性。方法　采用经典恒温加速试验考察了温度对黄芩苷水溶液的影响 ,并测定了黄芩苷水溶液的最稳定pH。结果　黄芩苷水溶液损失 10 %所需要的时间仅为 18 1h ,降解活化能为 79 1kJ·moL- 1 。黄芩苷的最稳定pH值采用实测值为 4 2 8。结论　黄芩苷水溶液受温度和pH的影响很大 ,因此在生产过程中 ,应尽可能保持低温 ,并调节溶液pH值使接近黄芩苷的最稳定pH。

关 键 词：RP-HPLC BAICALIN STABILITY TEMPERATURE PH 

分 类 号：R286[医药卫生—中药学]