鼻咽癌内血管内皮生长因子的表达及微血管密度的病理意义  

The Expression of Vascular Endothelial Growth Factor and the Pathological Significance of Microvascular Density in Nasopharyngeal Carcinoma

作　　者：何常[1] 张维元[1] 薄莉[1] 钟愉[1] 

机构地区：[1]贵阳医学院病理学教研室,贵州贵阳550004

出　　处：《贵阳医学院学报》2004年第3期196-197,200,共3页Journal of Guiyang Medical College

基　　金：贵州省科技厅基金资助项目 (E97 3)

摘　　要：目的 :探讨鼻咽癌内血管内皮生长因子 (VEGF)的表达及微血管密度 (MVD)的病理意义。方法 :应用免疫组织化学S P法对鼻咽癌内VEGF的表达及MVD进行检测。结果 :鼻咽癌内VEGF的阳性表达率为 83%(5 3/ 6 4 ) ,VEGF的表达及MVD均与患者的 5年生存率及淋巴结转移相关 (P <0 0 5 ) ,同时VEGF的表达与MVD呈正相关关系 (P <0 0 1)。结论Objective: To study the expression of vascular endothelial growth factor (VEGF), and the pathological significance of microvascular density (MVD) in nasopharyngeal carcinoma (NPC). Methods: S-P method of immunohistochemistry was adopted to check the expression of VEGF protein and MVD in 64 cases of NPC. Results: The positive rates of VEGF in NPC was 83%. Both VEGF and MVD were correlated significantly with lymph node metastasis and 5-year survival rate (P<0.05). In addition, there was a close positive correlation between VEGF and MVD (P<0.01). Conclusion: The high expression of VEGF and high MVD correlate significantly with lymph node metastasis and faulty prognosis in patients of NPC.

关 键 词：鼻咽肿瘤 内皮生长因子 新生血管化 病理性 

分 类 号：R739.63[医药卫生—肿瘤]