咪唑[4,5-b]并吡啶类化合物的合成  

Synthesis of Imidazo[4,5-b] Pyridine Derivatives

作　　者：张军忍[1] 陈国华[1] 龙绪江[1] 魏宝康 路国荣 

机构地区：[1]中国药科大学药物化学教研室,南京210009 [2]厦门建发制药有限公司,厦门361001 [3]江阴福泰化工有限公司,江阴214415

出　　处：《中国药科大学学报》2004年第3期280-282,共3页Journal of China Pharmaceutical University

摘　　要：AIM:To search for new inhibitors with excellent activity and stability to (H ++K +)ATPase.METHOD:Beginning with 2-amino-6-chloro-3-nitropyridine,the title compounds were obtained by substitutioin,cyclization and oxidation.RESULT:Five new compounds were synthesized and the structure of the title compounds was identified by IR, 1HNMR and ESI-MS.Activity and stability of the five new compounds are on searching.AIM:To search for new inhibitors with excellent activity and stability to (H ++K +)ATPase.METHOD:Beginning with 2-amino-6-chloro-3-nitropyridine,the title compounds were obtained by substitutioin,cyclization and oxidation.RESULT:Five new compounds were synthesized and the structure of the title compounds was identified by IR, 1HNMR and ESI-MS.Activity and stability of the five new compounds are on searching.

关 键 词：H^+/K^+-ATP酶抑制剂 2-氨基-6-氯-3-硝基吡啶 合成 

分 类 号：R914.5[医药卫生—药物化学]