胃癌中VEGF,F1t1和P53的表达意义(英文)  

Expressions of VEGF, Flt1 and P53 and their significance in gastric carcinoma

作　　者：段伦喜[1] 钟德午[1] 胡辅珍[1] 赵华[1] 易文君[1] 华颂文[1] 

机构地区：[1]中南大学湘雅二医院普外科,湖南长沙410011

出　　处：《中国现代医学杂志》2004年第12期38-41,共4页China Journal of Modern Medicine

摘　　要：目的探讨胃癌中VEGF、F1t1、P53的表达意义。方法应用SABC免疫组化法,研究VEGF、F1t1、P53在胃癌中表达与胃癌生长转移、临床病理特征、预后的关系。结果胃癌VEGF表达与肿瘤侵润深度有关(P<0.01)。P53表达与淋巴转移相关(P<0.05)。VEGF与F1t1表达呈正相关(P<0.05)。影响胃癌预后的因素有临床病理分期、VEGF表达、肿瘤侵润深度和手术方式。Kaplan-Meier研究显示VEGF表达与胃癌生存预后相关(P<0.05),而F1t1、P53表达与生存预后无关(P<0.05)。结论胃癌患者检测VEGF及P53表达有重要意义。Objective: To investigate the expressions of VEGF, Flt1 and P53 in gastric carcinoma and its significance. Methods: Using SABC immunohistochemical method, the expressions of VEGF, Flt1 and P53 in gastric carcinoma were studied and their correlations with tumor growth, clinicopathological characteristics and prognosis were explored. Results: The expression of VEGF in gastric carcinoma was related to the depth of tumor invasion (P<0.01). There was a correlation between P53 expression and lymphatic metastasis (P<0.05). A significant positive relation was found between the expressions of VEGF and Flt1 (P<0.005). The factors affecting prognosis were clinicopathological staging, VEGF expression, the depth of tumor invasion and surgical manner. Kaplan-Meier study showed a relation between survival and prognosis of patients with gastric carcinoma and VEGF expression (P<0.05) but not the expression of P53 or Flt1 (P>0.05). Conclusion: Detection of VEGF and P53 expressions is of great importance in gastric carcinoma.

关 键 词：胃癌 SABC法 VEGF F1t1 P53 

分 类 号：R735.2[医药卫生—肿瘤]