银杏叶片对化学诱导急性肝坏死大鼠的作用  

Effect of Ginkgo Biloba Extract on Rats with Acute Liver Necrosis by Chemical Induction

作　　者：何云[1] 袁凤仪[1] 杜东红[1] 

机构地区：[1]解放军第44医院,贵阳550009

出　　处：《西南军医》2004年第3期3-4,共2页Journal of Military Surgeon in Southwest China

基　　金：成都军区"十五"医药卫生科研课题 (0 1A0 0 1)

摘　　要：目的　观察银杏制剂对急性肝损害大鼠的保护作用。方法　腹腔内注射 10 %D 氨基半乳糖致动物急性肝损伤 ,分为模型组、预防 1和 2组 (给银杏制剂 )及阳性对照组 (给齐墩果酸片 ) ,另有空白对照组及给等量的蒸馏水灌胃 ,1天 1次 ,共 7天。末次给药后 ,禁食 2 4h后断头取血及留肝组织作病理检查。结果　模型组大鼠血中PAF和ALT明显升高 ,病理肝脏细胞明显变性坏死 ,而预防组大鼠各项指标明显改善 ,病理损害程度也明显减轻。结论　银杏内酯能部分阻断PAF对肝脏的损害 。Objective To observe the protective effect of ginkgo biloba extract on rats with acute liver necrosis. Methods Intraperitoneal injection of 10% D GaIN was given to produce acute liver necrosis.The rats were divided into Model Group,Prevention Group 1 and 2 (given ginkgo biloba extract),Positive Control Group (given Oleanolic Acid Tablet)and Normal Control Group (given steamed water of same amount);Stomach perfusion was given once a day for 7 days,and then fast started.After fasting for 24 hours,the rats were killed and the blood and liver tissues were taken for pathological examination. Results PAF and ALT in blood in Model Group raised greatly, the pathological examination showed significant degenerative necrosis in liver cells,while in Prevention Group,clear improvement were found in all the index,and the pathological damage decreased. Conclusions Ginkgolide has certain protective effect for liver as it can partly block the damage of PAF to liver.

关 键 词：银杏制剂 急性肝坏死 氨基半乳糖 

分 类 号：R-332[医药卫生]