槟榔提取物对内皮细胞分泌一氧化氮的影响  

The effect of aqueous areca nut extract on the level of NO produced by endothelial cells

作　　者：李霞[1] 凌天牖[1] 

机构地区：[1]中南大学湘雅二医院口腔科,湖南长沙410011

出　　处：《临床口腔医学杂志》2004年第8期463-464,共2页Journal of Clinical Stomatology

摘　　要：目的 :探讨口腔黏膜下纤维性变 (OSF)可能的发病机理。方法 :用槟榔提取物干预体外培养的内皮细胞 ,收集培养上清 ,用ELISA方法检测内皮细胞分泌一氧化氮 (NO)的浓度。结果 :槟榔提取物能抑制体外培养的内皮细胞分泌NO。结论 :OSF的发生可能与槟榔引起的内皮细胞合成NO减少有关。Objective:To investigate the pathogenesis of oral submucous fibrosis.Method:Stimulated the endothelial cells with aqueous areca nut extract(AANE) and the cultured medium was aspirated. Then the level of NO produced by endothelial cells was detected by method of ELISA.Result:The level of NO produced by endothelial cells was inhibited by AANE.Conclution: Endothelial cells stimulated by areca nut producing less level of NO may induce OSF.

关 键 词：槟榔提取物 内皮细胞 一氧化氮 

分 类 号：R781.5[医药卫生—口腔医学]