肠易激综合征患者血浆VIP与食管动力学关系的研究  

Relationship between VIP and esophageal dymamics in patients with irritable bowel syndrome

作　　者：王如华[1] 陈尼维[1] 陈维雄[1] 朱金水[1] 罗小蓉[1] 

机构地区：[1]上海交通大学附属第六人民医院消化科,上海200233

出　　处：《现代医药卫生》2004年第13期1196-1197,共2页Journal of Modern Medicine & Health

摘　　要：目的 :探讨血浆VIP对肠易激综合征 (IBS)患者食管动力的影响。方法 :对40例肠易激综合征患者和20例健康人 (HS) ,采用放免法测定血浆VIP含量 ,采用核素法测定食管液体通过时间和胃食管反流。结果 :IBS组血浆VIP显著高于HS组 (P<0 05) ;IBS组胃食管反流率显著高于HS组 (P<0 05) ;IBS组中胃食管反流阳性组血浆VIP显著高于胃食管反流阴性组 (P<0 05) ;IBS组食管液体总通过时间与HS组相比结果差异无显著性 (P>0 05)。结论 :IBS患者血浆VIP含量的升高可使食管下括约肌 (LES)松弛而产生胃食管反流。Objective:To explore the effects of plasma vasoactive intestinal peptide(VIP)on the esophageal dynamics in patients with irriˉtable bowel syndrome(IBS).Methods:Plasma VIP concentration with radioimmunoassay(RIA)and esophageal liquid transit time and gastroeˉsophageal refluxwith scintigraphy were detected in40patients with IBS and20healthy subjects(HS).Results:The plasma levels of VIP in patients with IBS were markedly higher than those in HS(30.43±9.76vs15.12±7.03,P<0.05).There was significant difference of gastroesophageal reflux rate between IBS group and HS group(52.5%vs10%,P<0.05).Among IBS,the plasma levels of VIP in patients with gastroesophageal reflux group were markedly higher than those in non-gastroesophageal reflux group(38.24±10.34vs19.45±8.52,P<0.05).There was no significant difference of esophageal liquid transit time between IBS and HS group(P>0.05).Conclusion:VIP may influence lower esophageal sphincter and cause gastroesophageal reflux in patients with IBS.

关 键 词：肠易激综合征 血浆VIP 食管动力学 放免法 测定 

分 类 号：R574.4[医药卫生—消化系统]