吉派林纳洛酮联合治疗急性脑梗塞的疗效观察  

Clinical observations on the therapeutic effect of LMWH sodium injection and NH in treatment of acute cerebral infarction

作　　者：黄立相 吕龙 黎剑泉 杨晓红 

机构地区：[1]广东省丰顺县人民医院,广东丰顺514300

出　　处：《河北医学》2004年第7期645-647,共3页Hebei Medicine

摘　　要：目的 :观察吉派林纳洛酮联合治疗急性脑梗塞的疗效。方法 :将 80例诊断明确的急性脑梗塞患者 ,随机分为 2组 :治疗组 4 0例 ,纳洛酮 0 .8mg加入生理盐水 2 5 0mlivdripqd× 14d ;吉派林5 0 0 0IU腹壁皮下注射 ,q12h× 7d ,停用吉派林后口服阿司匹林肠溶片 75mgqd。对照组 4 0例 ,低分子右旋糖酐 5 0 0ml加维脑路通注射液 0 .4givdripqd× 14d ,同时口服阿司匹林肠溶片 75mgqd。按临床神经功能缺损程度评分标准于治疗前后 14d进行疗效评定。结果 :经一个疗程治疗后 ,治疗组神经功能缺损程度恢复较快 (P <0 .0 5 ) ,基本痊愈率较高 (P <0 .0 1)。结论 :吉派林纳洛酮联合治疗急性脑梗塞 ,临床疗效肯定 ,且无明显不良反应。Objective: To observe the curative effect in treatment of acute cerebral infarction with Low Molecular Weight Heparin Sodium Injection (LMWH )and Noloxone Hydrochloride Narcan (NX). Method: We selected 80confirmed case of acute cerebral infarction .The subjects were randomly divided into 2 groups : In the trial group there were 40 cases who were treated with 0.9%NS 250ml plus NX 0.8mg iv drip qd ×14d ,and after they were treated with LMWH 5000IU ih q12h×7d, we let them take aspirin(ES) 75mg by one times a day . In the controlled group there were 40 cases who were treated with Dextran 40(Rhentran) 500ml plus venoruton injection 0.4g iv drip qd × 14d, at the same time they were treated with aspirin (ES) 75mg by one times a day. We judged the clinical nervous function defect degree before and 14d treatment according to the nervous defect standard (NDS) to analyze the curative effect. Result: After one course of treatment ,There was an apparent difference in the recovery of clinical nervous function defect degree(P<0.05) and there was a significant difference in the curative rate(60% Vs 30% P<0.01) between the trial group and the control group. Conclusion: The curative effect of LMWH and NX are satisfactory without any toxic and side effects . These results suggest that LMWH and NX are effective and safe medicine in the treatment of acute cerebral infarction.

关 键 词：吉派林 纳洛酮 急性脑梗塞 

分 类 号：R743.33[医药卫生—神经病学与精神病学]