血管内支架结合电解可脱卸弹簧圈治疗犬颈动脉宽颈动脉瘤的实验研究  

Endovascular treatment of wide-necked aneurysms using stents combined with electrolytic detachable coils in a canine model

作　　者：刘建民[1] 张鑫[1] 周晓平[1] 洪波[1] 许奕[1] 黄清海[1] 张珑[1] 佘家贵[1] 赵瑞[1] 

机构地区：[1]上海第二军医大学长海医院神外科,200433

出　　处：《介入放射学杂志》2004年第3期258-262,共5页Journal of Interventional Radiology

基　　金：上海市科委重点课题 (O3D2 1970 6)

摘　　要：目的　通过支架植入及结合电解可脱卸弹簧圈治疗犬颈动脉宽颈侧壁囊性动脉瘤实验研究评价动脉瘤栓塞后的血流动力学及组织学改变。方法　于 6只健康犬双侧颈动脉分别建立宽颈侧壁动脉瘤 ,一侧单纯支架植入 ,对侧行支架植入结合弹簧圈栓塞。行血管超声和血管造影检查 ,并观察大体解剖及电镜检查。结果　单纯支架植入的动脉瘤内无血栓形成 ,瘤颈处新生内膜生长较慢 ,而支架结合弹簧圈治疗的动脉瘤内很快形成血栓 ,新生内膜能完全覆盖动脉瘤颈。结论　血管内支架结合电解可脱卸弹簧圈治疗宽颈动脉瘤不但可以降低动脉瘤再破裂的风险 。Objective To assess hemodynamics and histology of the aneurysms by treating experimental wide necked aneurysms endovascularly with a combination of stents and electrolytic detachable coils.Methods An experimental model was surgically constructed in the necks of six canines for simulating intracranial wide necked aneurysms. Balloon expandable metal stents were positioned across the aneurysms in bilateral carotid arteries of six canines with additional intraaneurysmal placement of detachable microcoils in only unilateral carotid artery of each canine. Sonography and angiography were performed in different stages and histologic examinations were achieved finally. Results Stent placement was successful in all six canines. Aneurysms treated with only stents placement showed no significant thrombus formation with slow growing of neointima over the neck of the aneurysm. Thrombosis occurred in the aneurysms treated with stents and coils in a short time and neointima covered the neck of the aneurysms completely.Conclusions Endovascular treatment of wide necked aneurysms using stents combined with electrolytic detachable coils may prevent re rupture of the aneurysms and promote neointima formation over the neck of the aneurysms.

关 键 词：血管内支架 可脱卸弹簧圈 犬 颈动脉 宽颈动脉瘤 介入治疗 肿瘤 

分 类 号：R739.91[医药卫生—肿瘤]