胰岛素样生长因子Ⅱ过度分泌引起的非胰岛细胞肿瘤性低血糖——2例报告与文献复习  

Non-islet cell tumor-induced hypoglycemia due to overproduction of insulin-like growth factor-Ⅱ——two case reports and literature review

作　　者：陆洁莉[1] 赵咏桔[1] 唐金凤[1] 刘建民[1] 王卫庆[1] 张炜[1] 顾燕云[1] 罗邦尧[1] 李小英[1] 宁光[1] 

机构地区：[1]上海第二医科大学附属瑞金医院内分泌代谢病科

出　　处：《中华内分泌代谢杂志》2004年第3期234-235,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：上海市教委重点学科建设经费资助 (2 0 0 3年 )

摘　　要：2例非胰岛细胞肿瘤性低血糖 (NICTH)患者血清中胰岛素样生长因子 (IGF) Ⅱ水平增高 ,IGF Ⅰ、IGF结合蛋白 (BP) 3、GH水平受到抑制 ,IGF Ⅱ /IGF Ⅰ异常增高 ,其中 1例间质来源的肿瘤患者术后循环GH IGF轴恢复至正常范围 ,表明循环GH IGF轴改变在NICTH的定性诊断中具有重要价值 ,IGF Ⅱ /IGFThe relationship between abnormal circulating GH-insulin-like growth factor (IGF) axis and hypoglycaemia was explored in 2 cases of non-islet cell tumor associated hypoglycaemia (NICTH). Serum level of IGF-Ⅱ was increased, the levels of GH, IGF-Ⅰ, IGFBP-3 were decreased to some extent, and IGF-Ⅱ/IGF-Ⅰ (molar ratio) was significantly increased in these two cases. In one case, circulating GH-IGF axis returned to normal after complete removal of the tumor. In the diagnosis of NICTH, the abnormal circulating GH-IGF axis is quite valuable and IGF-Ⅱ/IGF-Ⅰ appears to be a more sensitive parameter.

关 键 词：胰岛素样生长因子Ⅱ 非胰岛细胞肿瘤性低血糖 文献复习 循环GH—IGF轴 

分 类 号：R730.4[医药卫生—肿瘤]