脑质子磁共振波谱在早期帕金森病诊断中的价值  

Diagnostic Value of Proton Magnetic Resonance Spectroscopy in Early-stage Parkinson’s Disease

作　　者：黄海东[1] 邓敬兰[1] 宦怡[2] 杨春敏[2] 葛雅丽[2] 赵海涛[2] 

机构地区：[1]第四军医大学西京医院核医学科,陕西西安710032 [2]第四军医大学西京医院放射科,陕西西安710032

出　　处：《实用放射学杂志》2004年第6期486-488,572,共4页Journal of Practical Radiology

摘　　要：目的　探讨质子磁共振波谱 ( 1H -MRS)在早期帕金森病 (Parkinson’sdisease ,PD)诊断中的临床应用价值。方法　对 10例偏侧PD患者 (Hoehn -YahrⅠ级 )和 10例年龄匹配正常对照者双侧基底节区进行 1H -MRS检测 ,对比分析PD患者患侧肢体对侧和同侧以及正常对照者的基底节区N -乙酰基天门冬氨酸 (NAA) /肌酸复合物 (Cr)和胆碱复合物 (Cho) /Cr比值的变化。结果　PD组患者患侧肢体对侧的基底节区NAA/Cr比值显著低于同侧和正常对照组 (P <0 .0 5 ) ,Cho/Cr比值显著高于同侧和正常对照组 (P<0 .0 5 ) ;PD组患者患侧肢体同侧的基底节区NAA/Cr和Cho/Cr比值与正常对照组比较无显著差异 (P >0 .0 5 )。结论　1HObjective To explore the clinical applied value of proton magnetic resonance spectroscopy ( 1H-MRS) in diagnosis of early-stage Parkinson’s disease(PD).Methods 1H-MRS in the both basal ganglia was carried out in 10 PD patients with unilateral symptoms ( Hoehn-Yahr stageⅠ) and 10 age-matched healthy control subjects. The metabolic ratios of N-acetylasparatate (NAA)/creatine (Cr), and choline-containing compounds(Cho)/Cr in the basal ganglia contralateral to the affected limbs of PD patients were compared with those in the basal ganglia ipsilateral to the affected limbs of PD patients and those in the both basal ganglia of the age-matched healthy control subjects.Results NAA/Cr ratios were reduced significantly and Cho/Cr ratios were increased significantly in the basal ganglia contralateral to the affected limbs of PD patients compared to those in the basal ganglia ipsilateral to the affected limbs of PD patients and those in the both basal ganglia of the healthy controls(P<0.05). However, no significant differences in NAA/Cr and Cho/Cr ratios were found between the basal ganglia ipsilateral to the affected limbs of PD patients and the both basal ganglia of healthy controls(P>0.05).Conclusion 1H-MRS is a noninvasive technique that can provide useful information concerning the pathological changes of nerve cell in the basal ganglia of PD patients with unilateral symptoms.

关 键 词：脑 帕金森病 磁共振波谱 基底节区 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]