谷氨酸对丘脑束旁核痛反应神经元放电的影响  

THE EFFECT OF GLUTAMATE ON ELECTRIC DISCHARGE OF PAIN-RELATED NEURONS IN NUCLEUS PARAFASCICULARIS OF THALAMUS

作　　者：闫彬彬[1] 徐满英[1] 肖辉[2] 关艳中[1] 张秀娟[1] 

机构地区：[1]哈尔滨医科大学生理教研室,哈尔滨150086 [2]哈尔滨医科大学附属第二医院

出　　处：《中国疼痛医学杂志》2004年第3期170-172,共3页Chinese Journal of Pain Medicine

基　　金：国家自然科学基金资助项目;No :30 2 4 0 0 5 8;黑龙江省科技攻关资助项目 ;No :GC0 1C14 1 0 1

摘　　要：目的 :研究脑室注射谷氨酸 (Glu)对大鼠丘脑束旁核痛反应神经元电活动的影响。方法 :以电脉冲刺激右侧坐骨神经作为伤害性刺激 ,用玻璃微电极细胞外记录神经元的放电。结果 :脑室注射Glu (1.5 μg /10 μl)可使痛兴奋神经元 (PEN)放电频率的净增值增加 ,潜伏期缩短 ;使痛抑制神经元 (PIN)的抑制时程明显延长 ,放电频率的净增值降低。结论 :Glu能加强PEN和抑制PIN的电活动 ,提示Glu在痛觉调制中起兴奋作用 ,介导中枢伤害性信息的传递。Objective: To study the effects of Glutamate (Glu) intracerebroventricular (icv) injection on the electric activities of pain-related neurons in the thalamic nucleus parafascicularis in rat. Methods: Trains of the electric impulses applied to the right sciatic nerve were used as noxious stimuli,the discharges of neurons were led out by extracellular recording method with glass microelectrodes. Results: Icv injection of Glu (1.5μg / 10μl) resulted in an increase of the net-increased value (NIV) of frequency of evoked discharge of the pain-excited neurons (PEN) and a shorter latency of PEN;the inhibitory duration of the pain- inhibited neurons (PIN) was prolonged and the NIV of PIN was reduced. Conclusion: Glu showed the excited effect of discharge in the PEN as well as the inhibitory effect of discharge in the PIN,which suggested that Glu transmitted the noxious information and played an excited role in the regulating pain.

关 键 词：谷氨酸 丘脑束旁核 痛反应神经元 脑室注射 神经元放电 痛抑制神经元 

分 类 号：R741[医药卫生—神经病学与精神病学]