人与猪肝门静脉显微结构成分的比较  

Comparison of microstructural component between human and pig hepatic portal vein

作　　者：王配军[1] 王汉琴[1] 李文春[1] 张一飞[1] 孙万群[1] 黄铁柱[1] 

机构地区：[1]郧阳医学院解剖学教研室,十堰442000

出　　处：《解剖学杂志》2004年第3期309-311,F004,共4页Chinese Journal of Anatomy

基　　金：湖北省教育厅科研资助项目 (2 0 0 2z0 30 0 4 )

摘　　要：目的 :比较人与猪肝门静脉壁结构成分的异同 ,为猪→人异种肝移植提供理论依据。方法 :取正常成人与不同月龄猪肝门静脉 ,常规石蜡包埋、切片 ,分染弹性纤维、胶原纤维和平滑肌 ,光镜观察 ,计算机图像分析系统测量各结构成分的相对含量。结果 :随月龄的增长猪肝门静脉胶原纤维的含量逐渐升高 ,弹性纤维的含量相对稳定 ,平滑肌的含量在 3月龄时最高 ,C/E值逐渐升高。与人相比 ,猪肝门静脉壁中胶原纤维和弹性纤维的含量较低 ,而平滑肌的含量则较高 ,5、6月龄时的C/E值与人相近。结论 :人与猪肝门静脉壁各结构成分的含量存在差异 ,但从C/E值看 ,5、6月龄猪肝门静脉的力学特性与人相匹配 ,较适合用于移植。Objective: To compare the microstructural components between human and pig hepatic portal vein, providing evidence for pig to human liver xenotransplantation. Methods: The hepatic portal veins of human and swine were collected and serially sectioned by paraffin section methods.Elastic fibers, collagen fibers and smooth muscles were stained by Weigert,Aniline blue and orange G respectively and were measured with image analysis system at light microscopic level.Results: In the hepatic portal vein, the collagen fibers increased with increase of age, the elastic fiber kept relatively stable and smooth muscle were the greatest in 3 months.Compared with human,the content of elastic fibers and collagen fibers were lower in swine,while the content of smooth muscle was higher. There was no difference in C/E between the vessels in 5,6 months old pig and human.Conclusion: There was difference in the content of microstructural components between the hepatic portal vein of human and pig,but C/E is feasible for anastomosis of hepatic portal vein in the 5,6 months pig and human.

关 键 词：猪 肝门静脉 显微结构 异种肝移植 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学]