脑梗死患者血小板内钙水平测定意义  

To detect the exponent of Ca^(2+) in blood platelet of the patients with cerebral infarction

作　　者：薛慎伍[1] 邓丕兰[1] 李积胜[2] 李朝福[2] 

机构地区：[1]济南军区总医院神经内二科,山东济南250031 [2]武警医学院,天津300162

出　　处：《中风与神经疾病杂志》2004年第3期245-246,共2页Journal of Apoplexy and Nervous Diseases

摘　　要：目的　血小板内钙水平改变对脑缺血影响 ,拟探讨治疗对策。方法　采用流式细胞仪定量检测。结果　脑梗死组血小板中Ca2 + 指数 (IECa2 + )显著高于对照组 (P <0 .0 1)。中、重度患病组又显著高于轻患组 (P <0 .0 1、P <0 .0 5 )。性别间存在男性高于女性的显著差异 (P <0 .0 5 )。结论　血小板内Ca2 + 水平增高是诱发脑缺血性损害的因素之一。Objective We surveyed the exponent of Ca 2+ in blood platelet of the patients with cerebral infarction to study the therapy method. Methods We used flow cytometry instrument to detect the exponent of Ca 2+. Results The exponents of Ca 2+ in blood platelet of the the patients with cerebral infarction were higher than the group of control(P< 0.01). The exponents of groups of moderate and serious disease patients were higher than mild patients(P< 0.01), and exponent in male patient was higher than in female patient;P< 0.05. Conclusion The exponent of Ca 2+ in blood platelet increasing may induce cerebral ischemic injury.

关 键 词：脑梗死 血小板 钙 测定 脑缺血 信号转导 

分 类 号：R743.33[医药卫生—神经病学与精神病学]