利福霉素B的选育及其发酵的研究  

Study of Rifamycin B Selection and Fermentation

作　　者：赵日红[1] 王高升[1] 马秋生[1] 

机构地区：[1]哈药集团制药总厂,150086

出　　处：《黑龙江医药》2004年第4期291-293,共3页Heilongjiang Medicine journal

摘　　要：目的:寻找新的菌种提高利福霉素B的发酵水平。方法:对菌株 AmediterraneiXCl—02进行筛选、诱变,获得新的菌株。结果:获得高产菌株 AmediterraneiXC9—25,生产能力较原始出发菌株 AmediterraneiXCl—02提高1.385倍,效价达到10000u/ml。结论:通过工业方法产生菌株,并对其进行筛选变种是提高利福霉素 BObjective is to look for new strain to increase the level of Rifamycin B fermenta- tion.The method is to get the new strain from the selection and mutation of strain Amediter- raneiXC1—02.The result is to get productive strain of AmediterraneiXC9—25 that has 1.385 times production than the old strain of AmediterraneiXC1—02.and its potency is 10000u/ml.The conclusion is that it's the effective method to improve the production of Rifamycin B by industrial method to select and mutate the strain.

关 键 词：利福霉素B 选育 发酵 抗生素 

分 类 号：TQ465[化学工程—制药化工]