盐酸奈福泮及其注射液有关物质的HPLC测定  

Determination of Related Substances of Nefopam Hydrochlorideand Its Injection by HPLC

作　　者：毕晓冬 谢沐风[2] 

机构地区：[1]承德颈复康药业集团有限责任公司,河北承德067000 [2]上海市药品检验所,上海200233

出　　处：《中国医药工业杂志》2004年第7期412-414,共3页Chinese Journal of Pharmaceuticals

摘　　要：建立了反相高效液相色谱法测定盐酸奈福泮及其注射液的有关物质。采用ODSC18色谱柱,流动相为0.01mol/L庚烷磺酸钠溶液(用1.0%磷酸调至pH3.5)-乙腈(65∶35),流速1.0ml/min,检测波长210nm。盐酸奈福泮的检测限为0.26ng。A RP-HPLC method for determination of related substances of nefopam hydrochloride and its injectionwas established. An ODS C18 column was used with the mobile phase of 0.01 mol/L heptane sodium sulfonate solution(adjusted pH to 3.5 with 1.0% phosphoric acid)-acetonitrile (65∶35), at the detection wavelength of 210nm. The flowrate was 1.0ml/min. The detection limit of nefopam hydrochloride was 0.26ng.

关 键 词：盐酸奈福泮 注射液 有关物质 反相高效液相色谱 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.72[化学工程—制药化工]