脑卒中后抑郁的相关因素及西酞普兰治疗作用研究  

Related factors of post stroke depression and therapeutical effect of citalopram

作　　者：苗素云[1] 史以菊[2] 

机构地区：[1]泰安市中心医院神经内科,山东省泰安市271000 [2]泰山医学院药理学教研室,山东省泰安市271000

出　　处：《中国临床康复》2004年第19期3718-3719,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:探讨脑卒中后抑郁(post-strokedepression,PSD)的相关因素及治疗。方法:对68例PSD患者进行颅脑CT或MRI病灶定位,随机分为西酞普兰治疗组和对照组,治疗并随访6周。两组分别于治疗前和治疗后的1,2,6周末进行汉密顿抑郁量表(HAMD)和抑郁自评量表(SDS)评定,同时进行西酞普兰不良反应观察。结果:左半球病灶PSD的发生率68%(46/68)高于右半球病灶32%(22/68),半球前部病灶PSD的发生率56%(38/68)高于半球后部病灶44%(30/68)。西酞普兰于治疗的第1周起效,治疗6周后显效率为79%(27/34),有效率为91%(31/34),不良反应少而且轻微。结论:PSD的发生与病灶部位有关;西酞普兰治疗PSD安全有效。AIM:To investigate the related factors and therapy for poststroke depression(PSD). METHODS:Six eight patients with PSD were meascered with CT or MRI for lesion localization,and randomly divided into citalopram group and control group.Each patient was followed up for 6 weeks.The two groups were assessed with Hamilton Depression Scale and Self rating Depression Scale before and after treatment at the end of 1st,2nd and 6th week, respectively.The adverse reaction of citalopram was observed. RESULTS:The incidence of PSD among patients with left hemispher stroke(68%,46/68) was higher than that with right hemispher stroke(32%,22/68),meanwhile,anterior lesion location(56%,38/68) was higher than posterior lesion location(44%,30/68).In the citalopram group,the response time was in the first week and the obviously effective rate was 79%(27/34) and the effective rate was 91%(31/34) after 6 week treatment with less adverse reactions. CONCLUSION:The onset of PSD is related to the location of cerebral injury;Citalopram is an effective and safe antidepressant in the treatment of PSD.

关 键 词：脑卒中 抑郁 相关因素 西酞普兰 治疗 不良反应 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]