脑梗死急性期血栓调节蛋白、纤溶酶-抗纤溶酶复合物变化与内皮细胞损伤  

Changes of plasma thrombomodulin and plasmin-α2-antiplasmin complexes and endothelial cell injury in acute phase of cerebral infarction

作　　者：沈仙娣[1] 方晶[1] 严为宏[1] 

机构地区：[1]上海第二医科大学附属第九人民医院神经内科,上海市200011

出　　处：《中国临床康复》2004年第19期3788-3789,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:为探讨急性动脉血栓形成过程中血液病理生理变化,对脑梗死患者急性期的血浆中血栓调节蛋白(thrombomodulin,TM)、纤溶酶-抗纤溶酶复合物(plasmin-α2-antiplasmincomplexes,PAP)水平进行测定。方法:设立脑梗死组(n=48)和对照组(n=44),前组按梗死体积不同分为较大体积梗死亚组和腔隙性梗死亚组,分别测定急性期血浆TM,PAP水平。检测法为ELISA法。结果:脑梗死组TM为(3.98±0.86)μg/L,PAP为(474.30±191.54)μg/L,较对照组(3.51±0.32),(345.11±174.20)μg/L,明显升高(t=2.954,2.901,P<0.05)。较大体积梗死患者PAP为(553.9±148.63)μg/L,较腔隙梗死组(364.78±115.52)μg/L显著升高(t=4.239,P<0.05)。结论:脑梗死患者急性期TM的水平升高,反映局部动脉内皮细胞损伤严重,可根据PAP水平选择相应的治疗手段。AIM:To explore the pathophysiological changes of acute arterial thrombus information by measuring the thrombomodulin(TM),and plasmin α2 antiplasmin complexes(PAP) levels in acute cerebral infarct patients. METHODS:Cerebral infarction group(n=48) and control group(n=44) were set,and according to the cerebral infarct volume the former group was divided ino two subgroups: bigger volume subgroup and lacuna infarct subgroup.TM and PAP levels were measured respectively with ELISA method. RESULTS:TM and PAP levels were significant higher in cerebral infarction group[(3.98±0.86) μg/L,(474.30±191.54) μg/L,respectively] than those of control group[(3.51±0.32) μg/L,(345.11±174.20) μg/L,respectively](t=2.954,2.901,P< 0.05),patients with bigger infarct volume has higher PAP level[(353.9±148.63) μg/L] than those with lacuna infarct[(364.78±115.52) μg/L](t=4.239,P< 0.05). CONCLUSION:TM level increases significantly in acute cerebral infarct patients,reflecting severe injury of endothelial cell in local artery can be treated with relevant therapy according to the level of PAD.

关 键 词：脑梗死 急性期 血栓调节蛋白 纤溶酶-抗纤溶酶复合物 内皮细胞损伤 测定 

分 类 号：R743.33[医药卫生—神经病学与精神病学]