小剂量反复注射匹罗卡品制备颞叶癫癎大鼠模型  

A Lithium-pilocarpine Chronic Model of Epilepsy

作　　者：宋毅军[1] 田心[2] 

机构地区：[1]天津医科大学总医院神经内科,300070 [2]天津医科大学生物医学工程系

出　　处：《天津医药》2004年第7期415-417,共3页Tianjin Medical Journal

基　　金：天津市自然科学基金资助课题 (项目编号 :023613911)

摘　　要：目的 :探讨氯化锂 -匹罗卡品所致癫大鼠模型的新制备方法。方法 :利用小剂量多次注射匹罗卡品的方法制备颞叶癫大鼠模型后 ,测取慢性模型组大鼠脑电 ,计算病灶处的相关维数 (Dc值 )。结果 :此方法使急性期大鼠病死率降至35 % ,且癫持续状态的发生率提高到接近100 %。模型组大鼠病灶处脑电Dc值明显降低。结论Objective:To establish a new experiment approach in lithium-pilocarpine(Li-Pilo)model of epilepsy was created.Methods:A new experimental approach in Li-Pilo model was created by repeat adminisˉtration of low doses of pilocarpine.Correlation dimension(Dc)of EEG was also calculated to assess the temporal lobe epilepsy characteristic of the Li-Pilo model in chronic period.Results:This new approach decreased the mortality rate to35%and produced status epilepticus(SE)in approximately100%of rats.Dc of EEG in main lesion channels of temporal lobe epilepsy rats was significantly decreased.Conclusion:Systemic treatment of lithium-pretreated rats with several low doses of pilocarpine is a better experimental protocol in lithium-piˉlocarpine(Li-Pilo)model of epilepsy

关 键 词：小剂量 注射 匹罗卡品 制备 颞叶癫痫 大鼠 模型动物 

分 类 号：R742.1[医药卫生—神经病学与精神病学]