百岁方颗粒剂对脑梗死患者认知功能障碍的干预作用  

Effect of Baisuifang Granule on cognitive malfunction after cerebral infarction

作　　者：郑岚[1] 沈小珩[1] 王瑛[2] 李威[3] 翟宇[3] 唐学梅[3] 袁灿兴[4] 陈运[4] 李俊[4] 夏翔[1] 

机构地区：[1]上海第二医科大学附属瑞金医院中医科,上海200025 [2]上海第二医科大学附属瑞金医院神经内科,上海200025 [3]上海第二医科大学附属第九人民医院神经内科,上海200011 [4]上海中医药大学附属龙华医院神经内科,上海200032

出　　处：《中西医结合学报》2004年第4期258-261,共4页Journal of Chinese Integrative Medicine

基　　金：上海市科技发展基金资助项目 ( 2 0 0 1 2 0 0 3 )

摘　　要：目的 :探讨百岁方颗粒剂对脑梗死患者认知功能障碍的干预作用。方法 :选择脑梗死患者 16 0例 ,随机分为治疗组80例 ,对照组 80例 ,分别服用百岁方及尼莫地平 ,疗程为 2个月。观察治疗前后患者的简易智力状态检查表 (MMSE)、中医症状、神经功能缺损中国中风量表 (CSS)的积分改变及血液流变学、纤维蛋白原等各项指标。结果 :临床观察表明 ,百岁方能提高脑梗死患者MMSE积分 ,降低中医症状积分 ,降低CSS积分 ,改善血液流变学。两组中医症状疗效比较 ,治疗组总有效率为 76 .2 5 % ,对照组总有效率为 5 8.75 % ,治疗组明显优于对照组 (P <0 .0 5 ) ;治疗组的中医症状积分、CSS积分、血黏度高切均优于对照组 (P <0 .0 1)。结论Objective: To explore the mechanism of Baisuifang Granule in treating cognitive malfunction after cerebral infarction. Methods:One hundred and sixty patients with cerebral infarction were divided randomly into two groups. Eighty patients were treated with Baisuifang Granule and 80 with nimodipine for two months. Clinical observation and laboratory examinations were performed for Mini-Mental State Examination(MMSE), clinical symptoms, Chinese Stroke Scale(CSS), hemorrheological indexes and fibrinogen before and after the treatment.Results:Baisuifang Granule could improve MMSE, reduce the scores of clinical symptoms and CSS, and meliorate the blood rheology. The total effective rate for clinical symptoms in the Baisuifang treated group accounted to 76.25%, with statistical difference comparing to 58.75% of nimodipine treated group (P<0.05).There was significant difference in symptom integral, CSS and whole blood viscosity at the high shear rate, respectively (P<0.01). Conclusion:Baisuifang Granule is an effective Chinese medicine for treating cognitive malfunction after cerebral infarction.

关 键 词：百岁方颗粒剂 脑梗死 认知功能障碍 干预作用 尼莫地平 

分 类 号：R743.33[医药卫生—神经病学与精神病学]