鼻咽癌患者微波热疗联合放疗前后T细胞亚群的变化及预后价值  

Prognostic value of changes of peripheral blood T cell subsets after thermoradiotherapy for nasopharyngeal carcinoma

作　　者：裘宇容[1] 郑磊[1] 杨春莉[1] 魏东[1] 孙德华[1] 

机构地区：[1]第一军医大学南方医院检验科,广东广州510515

出　　处：《第一军医大学学报》2004年第7期818-820,共3页Journal of First Military Medical University

摘　　要：目的 探讨微波热疗联合放疗前后鼻咽癌患者外周血中T细胞亚群的变化及其预后价值。方法 用流式细胞仪检测了20例非癌症患者(对照组)和30例鼻咽癌患者微波热疗联合放疗前后及20例单纯放疗鼻咽癌病人T细胞亚群。结果 与对照组相比,鼻咽癌病人外周血CD3^+CD4^+细胞百分率及CD8^+CD28^+细胞百分率降低(P<0.01),CD3^+CD8^+细胞和CD8^+CD28^+细胞百分率明显升高(p<0.01),CD4/CD8比值降低(P<0.01)。微波热疗联合放疗后1个月,病人外周血CD3^+CD4^+细胞百分率及CD8^+CD28^+细胞百分率进一步降低,CD3^+CD8^+细胞和CD8^+CD28^-细胞百分率继续升高,3个月后上述结果仍进一步恶化,且与病人的存活期限有明显关系。结论 微波热疗联合放疗后病人的T细胞免疫功能在较长时间内是受抑制的。CD8^+CD28^+和CD8^+CD28^-T细胞亚群的检测对微波热疗联合放疗病人的预后有重要临床意义。Objective To assess the prognostic value of changes of peripheral blood T cell subsets after thermoradiotherapy for nasopharyngeal carcinoma (NPC). Methods Peripheral blood T cell subsets in 20 normal subjects (control group), 30 NPC patients undergoing thermoradiotherapy, and 20 NPC patients undergoing radiotherapy were detected by flow cytometry. Results The percentages of CD3^+CD4^+ and CD8^+CD28^+ cells were decreased and the percentages of CD3^+CD8^+ and CD8^+CD28^- cells increased as compared with the measurements in normal persons. One month after thermoradiotherapy, the percentages of CD3^+CD4^+ and CD8^+CD28^+ cells further decreased and the percentages of CD3^+CD8^+ and CD8^+CD28^- cells further increased, which continued to worsen 3 months after the treatment and appeared to be related to the survival of the patients. Conclusion T cell subsets of NPC patients are abnormal and their immune functions depressed in NPC patients within a long period after thermoradio- therapy. CD8^+CD28^+ and CD8^+CD28^- T cell subsets can be significant for prognostic assessment in these patients after ther- moradiotherapy.

关 键 词：鼻咽癌 微波热疗联合放疗 T细胞亚群 

分 类 号：R739.63[医药卫生—肿瘤]