天然药物五倍子与氟化钠对釉质脱矿的影响比较研究  

Comparison of Galla Chinesis and Sodium Fluoride on the demineralization of enamel in caries model

作　　者：朱昞[1] 李红[1] 李继遥[1] 周学东[1] 

机构地区：[1]四川大学华西口腔医学院,四川成都610041

出　　处：《牙体牙髓牙周病学杂志》2004年第6期322-325,共4页Chinese Journal of Conservative Dentistry

基　　金：国家自然科学基金资助项目 (3 0 171175 )

摘　　要：目的 :比较天然药物五倍子和化学制剂氟化钠对釉质脱矿的影响 ,为天然防龋药物的开发提供理论依据。方法 :利用连续培养系统建立牙齿龋病模型 ,经五倍子和氟化钠处理后 ,利用偏光显微镜和扫描电镜观察比较二者对牛牙釉质龋形成的影响。结果 :偏光显微镜和扫描电镜观察发现 :五倍子和氟化钠都能抑制釉质早期龋的形成 ,表现为釉质表面的破坏程度较轻 ,釉质表层连续完整 ,并在表层脱矿区观察到有再矿化区域的存在。但本实验浓度下五倍子的功效弱于氟化钠。结论 :在龋病模型中 ,本实验浓度的五倍子能够有效抑制釉质早期龋的形成 ,提示五倍子是一种具有防龋效果的天然药物。AIM:To compare the cariostatic effect of Galla Chinesis with that of the sodium fluoride in vitro .METHODS:Caries models were established in chemostat and treated with 4 000 mg/L Galla Chinesis 100 mmol/L sucrose,225 mg/L and 114 mg/L NaF with 100 mmol/L sucrose,sucrose only and distilled water.The demineralized bovine enamel blocks were investigated on both surface and section of enamel with SEM and polarized light microscope respectively.RESULTS:The results confirm that the Galla Chinesis and NaF can inhibit the formation of early stage of caries lesion. The destruction of lesion were mitigated when Galla Chinesis and NaF exist,demineralization lighten and remineralization can be observed.CONCLUSION:Galla Chinesis can prevent the development of cries lesion,which provide a new choice for caries prevention.

关 键 词：五倍子 氟化钠 抗龋作用 龋病模型 致龋菌 

分 类 号：R780.1[医药卫生—口腔医学]