左炔诺孕酮聚β-羟基丁酸酯微球小鼠抗生育实验  

Anti-birth Test of Levonorgestrel Poly(β-hydroxybutyrate) Sustained Release Microspheres in Mice

作　　者：王正容[1] 陆彬[1] 

机构地区：[1]四川大学华西药学院药剂学教研室,成都610041

出　　处：《中国药师》2004年第7期491-493,共3页China Pharmacist

基　　金：国家计划生育委员会基金项目 (编号 92 -0 -4 1)

摘　　要：目的 :考察左炔诺孕酮聚 β 羟基丁酸酯微球 (LNG PHB MS)的抗生育持续时间。 方法 :通过小鼠抗生育实验 ,采用随机分组 ,不同剂量给药 ,对小鼠阴栓检出时间、生育时间、产仔数、生育率、死亡率等进行评价。结果 :给药剂量为 12 0 ,6 0 ,30 ,10mg·kg-1的微球组其避孕时间分别为 96 ,6 9.3,5 0 .4 ,2 7.2d ,各剂量组的避孕时间有显著性差异 ;而剂量为 12 0mg·kg-1和 6 0mg·kg-1的原药组死亡率高于 70 % ,剂量为 30mg·kg-1和 10mg·kg-1的原药组仅能维持 34.4d和 11.9d的避孕效果。结论 :LNG PHB MS不仅能显著延长避孕时间 ,而且能明显地降低毒副作用和给药剂量。Objective: To investigate an anti birth duration of LNG PHB MS in mice.Method: The anti birth effect was evaluated in the light of interference in sexual behavior, birth time, number of baby mouse, ratio of birth, and ratio of death, based on a random group divided and administration of different doses.Result: At those microspheres groups, When drugs were administrated, 60, 30, and 10 mg·kg -1 , respectively, the mice showed an anti pregnancy duration of over 3 months, 69.3 days, 50.4 days and 27.2 days, respectively,there was a significant differince in each dose's group. But at those pure drug groups, the mortalities due to severe side effects in the doses group with 120 mg·kg -1 and 60 mg·kg -1 were higher than 70%.It had only the anti birth time of 34.4 days and 12 days with a dose of 30 mg·kg -1 and 10 mg·kg -1 , respectively.Conclusion: LNG PHB MS not only can prolong the anti birth duration, but also decrease the dose and side effects. Furthermore, the PHB do not interfere with the sexual behavior and the reproductive function in mice.

关 键 词：抗生育实验 生育率 死亡率 左炔诺孕酮 聚Β-羟基丁酸酯 缓释微球 

分 类 号：R977.12[医药卫生—药品]