PTEN蛋白阳性在非小细胞肺癌的临床意义  

Expression and clinical significance of PTEN in non-small cell lung cancer

作　　者：刘文健[1] 王哲海[2] 何美清[3] 张本华[1] 仲卫霞[2] 刘杰[2] 曹文英[2] 田国栋[2] 

机构地区：[1]泰山医学院附属医院肿瘤科,山东泰安271000 [2]山东省肿瘤医院,山东济南250117 [3]泰山疗养院内三科,山东泰安271000

出　　处：《中国癌症杂志》2004年第3期240-242,246,共4页China Oncology

摘　　要：目的 :研究PTEN蛋白阳性对非小细胞肺癌临床意义。方法 :应用免疫组化SP法检测 10例正常肺组织和 5 6例非小细胞肺癌中PTEN基因的表达。结果 :非小细胞肺癌中PTEN蛋白阳性率为 5 9% ,而正常组织均阳性。PTEN蛋白阳性与肿瘤组织分化程度、临床分期以及有无淋巴结转移相关。PTEN蛋白阴性者预后较差。结论 :从蛋白水平揭示PTEN基因与非小细胞肺癌发展有关 。Purpose:To study the expression and clinical significance of PTEN in non-small cell lung cancer. Methods:Immunohistochemical staining was used to determine the expression of PTEN in 10 cases of normal lung issues and 56 cases of non-small cell lung cancer. Results:The positive incidences of PTEN expression in NSCLC was 59% while positive expression was found in all normal lung issues. The expression of PTEN was correlated to degree of differention of cancer, lymph node metastasis and clinical stages. The PTEN negative group was seen to have the worst survival rate among all groups. Conclusions:The results suggest that PTEN gene plays an important role in carcinogenesis and progress of NSCLC. Expression of PTEN may be valuable in prognosis assessment of NSCLC.

关 键 词：PTEN蛋白 非细胞肺癌 免疫组化染色 预后 

分 类 号：R734.2[医药卫生—肿瘤]