吉西他滨联合氟尿嘧啶治疗晚期肝外胆管癌  

Advanced cholangiocarcinoma treated with gemcitabine combined with 5-FU: An initial study of short-term therapeutic effect

作　　者：王梅[1] 龚彪[2] 姜斌[1] 薛春燕[1] 

机构地区：[1]第二军医大学长海医院肿瘤科,上海200433 [2]第二军医大学东方肝胆外科医院内镜科,上海200433

出　　处：《中国癌症杂志》2004年第3期282-283,共2页China Oncology

摘　　要：目的 :观察吉西他滨 (健择 )联合氟尿嘧啶治疗晚期肝外胆管癌的近期疗效。方法 :2 1例晚期胆管癌患者采用GLF方案化疗 :健择 10 0 0mg/m2 ,静脉滴注 30～ 6 0分钟 ,第 1,8天给药。亚叶酸钙 2 0 0mg/m2 ,静脉滴注 ,第 1～ 5天。氟尿嘧啶 6 0 0mg/m2 ,静脉滴注 2小时 ,第 1～ 5天。 2 1天为一个周期。结果 :2 1例中无 1例达完全缓解 ,部分缓解 5例 (2 3.8% ) ,稳定 8例 (38.1% )。 12例 (5 7.14 % )患者疼痛得到缓解 ,生活质量提高。结论Purpose:To observe the therapeutic effect of gemcitabine combined with 5-FU for the treatment of advanced cholangiocarcinoma. Methods:21 patients were given gemcitabine and 5-FU intravenously. Results:There was no complete response .The partial response rate was 23.8% and SD,38.1%.12 patients(57.14%) had amelioration of pain and improvement in quality of life.The toxicity was low and tolerable. Conclusions:Gemcitabine combined with 5-FU was an effective and safe regimen for treating advanced cholangiocarcinoma and worthy of further evaluation.

关 键 词：胆管癌 吉西他滨 氟尿嘧啶:联合化疗 

分 类 号：R735.8[医药卫生—肿瘤]