N-(4-芳酰胺基苯基)甲磺酰胺类化合物的合成及抗炎活性  

Synthesis and anti-inflammatory activity of N-(4-arylamidophenyl)methanesulfonamide derivatives

作　　者：楼永军[1] 董金华[1] 徐莉英[1] 计志忠[1] 

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016

出　　处：《药学学报》2004年第7期518-520,共3页Acta Pharmaceutica Sinica

摘　　要：目的　研究N (4 芳酰胺基苯基 )甲磺酰胺类化合物的抗炎作用。方法　以对硝基苯胺为起始原料经三步反应合成目标化合物 ,并以二甲苯致小鼠耳肿胀模型测试目标化合物的抗炎活性。结果　共合成 11个化合物 ,经IR ,1 HNMR和MS光谱确证结构 ;初步药理试验结果显示大部分化合物对二甲苯致小鼠耳肿胀具有较强的抑制作用。结论　N (4 芳酰胺基苯基 )Aim To study the anti-inflammatory activity of N-(4-arylamidophenyl)methanesulfonamide derivatives. Methods The target compounds were synthesized from p-nitroaniline via three steps and were evaluated for anti-inflammatory activity with the model of xylene-induced ear edema in mice. Results Eleven compounds were obtained and confirmed by IR, 1HNMR and MS. Some compounds were shown to have significant anti-inflammatory activity. Conclusion N-(4-arylamidophenyl)methanesulfonamide showed appreciable anti-inflammatory activity.

关 键 词：苯甲酰苯胺 N-(4-氨基苯基)甲磺酰胺 N-(4-芳酰胺基苯基)甲磺酰胺 抗炎作用 

分 类 号：R915.11[医药卫生—微生物与生化药学] R916.41[医药卫生—药学]