SU5416对大鼠胰腺癌微血管密度的影响及意义  

Effects of Angiogenesis Inhibitor SU5416 on Microvessel Density in Rat Model of Pancreatic Cancer

作　　者：王兆春 侍立志[2] 陈紫平[2] 邹桂华[2] 所剑[3] 

机构地区：[1]深圳市松岗人民医院普外科,深圳518105 [2]深圳市宝安人民医院普外科,深圳518101 [3]吉林大学第一医院普外科,长春130021

出　　处：《中国普外基础与临床杂志》2004年第4期351-352,共2页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　研究SU5 4 16对大鼠胰腺癌微血管密度 (MVD)的影响 ,判定其在肿瘤生长和转移中的抑制作用。方法　采用二甲基苯丙蒽直接置入大鼠胰腺 ,建立临床类似胰腺癌的大鼠模型。将 6 0只SD大鼠胰腺癌模型随机分为 4组 ,分别自腹腔注射生理盐水 (对照组 )、5 氟尿嘧啶 ( 5 FU组 )、SU5 4 16制剂 (SU5 4 16组 )和 5 FU +SU5 4 16联合用药 (联合组 ) ,隔日 1次 ,连续 12周 ,于 13周后处死大鼠 ,剖腹测量其肿瘤的MVD。结果　对照组、5 FU组、SU5 4 16组和联合组肿瘤MVD分别为 ( 12 .3± 3.2 ) %、( 11.4± 3.8) %、( 2 .1± 1.5 ) %和 ( 1.8± 1.1) % ;联合组及SU5 4 16组肿瘤MVD明显低于 5 FU组和对照组 (P<0 .0 5 ) ,但 5 FU组与对照组比较差异无显著性意义(P>0 .0 5 )。结论　SU5 4 16能有效降低大鼠胰腺癌模型中的肿瘤MVD ,且与化疗药物联合应用具有协同作用。Objective To study the effects of angiogenesis inhibitor SU5416 on the microvessel density(MVD) of pancreatic cancer and to evaluate its influence on the growth and metastasis of pancreatic cancer. Methods A rat model of pancreatic cancer was established with dimethylbenzanthracine(DMBA). 60 rats with pancreatic cancer were randomly divided into 4 groups: saline group, 5 Fu group, SU5416 group, 5 Fu and SU5416 group. Thirteen weeks after injection, the microvascular density (MVD) of pancreatic cancer was detected.Results The microvascular densities (MVD) were (12.3±3.2)%, (11.4±3.8)%, (2.1±1.5)% and (1.8±1.1)% in the saline group, 5 Fu group, SU5416 group and 5 Fu+SU5416 group respectively. The MVDs in the SU5416 group and 5 Fu+SU5416 group were statistically lower than those in the saline group and 5 Fu group( P <0.05). There was no significant difference between the 5 Fu group and saline group( P >0.05). Conclusion SU5416 can inhibit the microvascular growth in pancreatic cancer. And the inhibition can be enhanced when combined with chemotheraputic drugs.

关 键 词：SU5416 大鼠 胰腺癌 微血管密度 肿瘤生长 肿瘤转移 抑制作用 

分 类 号：R735.9[医药卫生—肿瘤]